高级检索

多个肿瘤标志物联合检测诊断非小细胞肺癌的价值

Value of combined detection of multiple tumor markers in the diagnosis of non-small cell lung cancer

    摘要
  • 摘要:
      目的  探讨叶酸受体阳性循环肿瘤细胞(FR+-CTCs)、神经元烯醇化酶(NSE)、细胞角蛋白19片段(CYFRA21-1)联合检测在非小细胞肺癌(NSCLC)诊断中的价值。
      方法  选取本院2019年1月—2020年8月150例NSCLC患者为NSCLC组，100例肺部良性病变患者为良性病变组，健康体检者100例为对照组。比较3组FR+-CTCs、NSE、CYFRA21-1水平，采用受试者工作特征(ROC)曲线分析各项指标单独与联合检测的诊断效能。
      结果  NSCLC组FR+-CTCs、NSE、CYFRA21-1水平高于良性病变组、对照组，良性病变组FR+-CTCs、NSE、CYFRA21-1水平高于对照组，差异均有统计学意义(P < 0.05)。在TNM分期Ⅰ、Ⅱ期NSCLC患者中，FR+-CTCs阳性率高于NSE、CYFRA21-1差异有统计学意义(P < 0.05)。分析150例NSCLC患者临床病理特征发现，TNM分期为Ⅲ期及Ⅳ期、鳞癌、分化程度低、有淋巴结转移的患者FR+-CTCs、NSE、CYFRA21-1水平分别高于Ⅰ期及Ⅱ期、腺癌、分化程度高、无淋巴结转移的患者，差异有统计学意义(P < 0.05)。ROC曲线分析结果提示，联合检测的曲线下面积(AUC)、敏感度、特异度依次为0.938、90.1%、84.6%，均较单独检测具有更高的诊断效能，差异有统计学意义(P < 0.05)。
      结论  FR+-CTCs在NSCLC早期具有较高的检出率，FR+-CTCs、NSE、CYFRA21-1联合检测可以进一步提高诊断效能，对NSCLC的早期诊断具有重要意义。

     

    Abstract:
      Objective  To investigate the value of combined detection of folate receptor-positive circulating tumor cells (FR+-CTCs), neuronal enolase (NSE) and cytokeratin 19 fragment (CYFRA21-1) in diagnosis of non-small cell lung cancer (NSCLC).
      Methods  From January 2019 to August 2020, 150 patients with NSCLC were selected as NSCLC group, 100 patients with benign pulmonary lesions were selected as benign lesion group, and 100 healthy people in physical examinations were selected as control group. The levels of FR+-CTCs, NSE and CYFRA21-1 were compared among the three groups. The diagnostic efficacies of one indicator and combined detection were analyzed by receiver operating characteristic (ROC) curve.
      Results  The levels of FR+-CTCs, NSE and CYFRA21-1 in the NSCLC group were significantly higher than those in the benign lesion group and control group, and the levels of FR+-CTCs, NSE and CYFRA21-1 in the benign lesion group were significantly higher than those in the control group (P < 0.05). In the NSCLC patients with TNM stage Ⅰ and Ⅱ, the positive rate of FR+-CTCs was significantly higher than that of NSE and CYFRA21-1 (P < 0.05). The clinicopathological features of 150 patients with NSCLC were analyzed, and the levels of FR+-CTCs, NSE and CYFRA21-1 in patients with TNM stage Ⅲ and IV, squamous cell carcinoma, low differentiation and lymph node metastasis were significantly higher than those in patients with TNM stage Ⅰ and Ⅱ, adenocarcinoma, high differentiation and no lymph node metastasis (P < 0.05). ROC curve analysis showed that the area under curve (AUC), sensitivity and specificity of combined detection were 0.938, 90.1% and 84.6% respectively, which were significantly higher than those of single detection (P < 0.05).
      Conclusion  FR+-CTCs has a high detection rate in the early stage of NSCLC. Combined detection of FR+-CTCs, NSE and CYFRA21-1 can further improve the diagnostic efficiency, which is of great significance for the early diagnosis of NSCLC.

     

    • HTML全文
    • 参考文献(14)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回