Objective  To explore the value of neutrophil-lymphocyte ratio(NLR) and mean platelet volume (MPV) in predicting early neurological deterioration(END) in patients with acute ischemic stroke.

  Methods  A retrospective analysis was performed for 172 patients with acute cerebral infarction, and they were divided into END group and non-END group according to occurrence of END. The baseline data of the two groups was analyzed, the correlations between NLR, MPV and vascular load were analyzed by Spearman correlation, the risk factors of END were analyzed by multivariate Logistic regression, and the value of NLR and MPV in predicting early neurological deterioration was evaluated by Receiver Operation Characteristic (ROC) curve.

  Results  NLR was positively correlated with the number of stenosis(r=0.453, P < 0.001) and the degree of stenosis(r=0.307, P < 0.001), while MPV was positively correlated with the number of stenosis (r=0.246, P < 0.001). NLR (OR=2.771, 95%CI, 1.163 to 6.600, P=0.021) and MPV(OR=3.138, 95%CI, 1.772 to 5.556, P < 0.001) were independent risk factors for END. The ROC curve showed that the areas under the curve predicted by NLR and MPV were 0.722 (95%CI, 0.624 to 0.820, P < 0.001) and 0.770 (95%CI, 0.690 to 0.849, P < 0.001), and their best cutoff values were 3.6 and 8.3 fL, respectively. The sensitivities of NLR and MPV were 40.6% and 93.8%, respectively, and the specificities were 92.9% and 50.7%, respectively.

  Conclusion  NLR and MPV are independent risk factors of END at admission, which have certain value in predicting the occurrence of END in patients with acute ischemic stroke.