生物材料补片在食管癌根治术中的临床应用

洪流; 路艳; 王珂; 李倩

doi:10.7619/jcmp.20210533

生物材料补片在食管癌根治术中的临床应用

洪流¹,
路艳^2,,
王珂^1,,
李倩¹

1.
中国人民解放军空军军医大学西京医院消化外科, 陕西西安, 710032
2.
中国人民解放军空军军医大学西京医院预防保健科, 陕西西安, 710032

基金项目: 国家自然科学基金资助项目(82073210); 陕西省重点产业创新链(群)-社会发展领域项目(2019ZDLSF01-02-01)

详细信息

通讯作者:
路艳，王珂

路艳，王珂

中图分类号: R735;R61
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出版历程
- 收稿日期: 2021-01-11
- 网络出版日期: 2021-03-30
- 发布日期: 2021-03-27

Clinical application of biomaterial patch in esophageal cancer surgery

HONG Liu¹,
LU Yan^2,,
WANG Ke^1,,
LI Qian¹

1.
Digestive Surgery Department, Xijing Hospital of Air Force Military Medical University of Chinese People's Liberation Army, Xi′an, Shaanxi, 710032
2.
Preventive Health Department, Xijing Hospital of Air Force Military Medical University of Chinese People's Liberation Army, Xi′an, Shaanxi, 710032

摘要

摘要:
目的观察生物补片在食管癌根治术中加强修补吻合口的临床应用效果。
方法回顾性分析52例接受食管癌根治术经颈部吻合患者的临床资料, 采用随机法将患者分为补片组(n=25)和对照组(n=27)。补片组采用生物材料补片加强修补食管残胃吻合口, 对照组行颈部食管残胃吻合后不使用补片修补加固。记录补片组和对照组术中出血量、手术时间、首次排气时间、首次排便时间、住院时间和术后并发症的发生率。
结果补片组颈部切口感染发生率低于对照组, 差异有统计学意义(P < 0.05)。补片组未发生食管、气管瘘, 对照组出现1例食管、气管瘘。2组肺部感染、吻合口狭窄、吻合口瘘发生率和手术时间、首次排气时间、住院时间比较, 差异无统计学意义(P > 0.05)。
结论利用生物材料补片在食管癌根治术中对吻合口加强修补, 有助于降低切口感染发生率。
- 食管癌 /
- 生物材料补片 /
- 外科手术 /
- 切口感染
Abstract:
Objective To observe the clinical effect of biomaterial patch in strengthening anastomotic repair during radical resection of esophageal cancer.
Methods Totally 52 esophageal cancer patients receiving radical resection were involved in the retrospective study, and their data was retrospectively analyzed. These patients were randomly divided into patch group(n= 25) and control group(n=27). The patients of the patch group were reinforced with the biomaterial patch after esophagogastric stump anastomosis, while those of control group didn't use biomaterial patch. The intraoperative blood loss, operation time, first flatus time, first defecation time, length of hospital stay and incidence of postoperative complications were recorded in the patch group and the control group.
Results The incidence of incision infection in the patch group was significantly lower than that in the control group(P < 0.05). No esophageal tracheal fistula occurred in the patch group, while 1 case occurred sophageal tracheal fistula in the control group. There were no statistically differences between two groups in the incidence rates of pulmonary infection, anastomotic leakage and anastomotic stenosis, operative time, first flatus time and hospitalization time(P > 0.05).
Conclusion The application of biomaterial patch to repair anastomotic stoma during esophageal cancer surgery is helpful to reduce the incidence of incision infection.
- esophageal cancer /
- biomaterial patch /
- surgery /
- incision infection

HTML全文

表 1 补片组和对照组食管癌根治术患者疗效分析(x±s)[n(%)]

指标	补片组(n=25)	对照组(n=27)
手术时间/min	352.44±24.51	348.68±37.62
出血量/mL	138.35±62.28	142.47±51.62
首次排气时间/d	2.71±1.22	2.83±1.19
首次排便时间/d	3.78±2.12	3.69±1.93
住院时间/d	8.26±1.41	8.53±1.35
肺部感染	3(12.00)	4(14.81)
吻合口瘘	2(8.00)	3(11.11)
吻合口狭窄	0	0
颈部切口感染	2(8.00)^*	8(29.63)
食管、气管瘘	0	1(3.70)
与对照组比较, * P < 0.05。

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参考文献(12)

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