Abstract: Postoperative adhesion after tendon injury is a common orthopedic problem in clinic, and there is no effective preventive measures at present. In recent decades, with the in-depth study of the healing process and the pathophysiological mechanism of tendon adhesion, and the continuous development in the fields of surgery, medicine, tissue engineering, molecule and gene, the certain progresses were obtained in the prevention and treatment of tendon adhesion. This study reviewed the mechanism of tendon adhesion and the latest progress in prevention strategies on molecular, gene and tissue engineering levels.