Abstract: Recipe of Wumei Pills has been used as the main prescription for Jueyin disease since ancient times, and it is mainly used to treat cold limbs syndrome due to ascariasis. With the development of theory of traditional Chinese medicine, application range of Wumei Pills has gradually expanded and widely used in treating various diseases in clinic. In recent years, recipe of Wumei Pills shows a definite therapeutic effect in the treatment of malignant tumors. In this study, the researches on experimental and clinical application of Wumei Pills were reviewed in order to provide new ideas for the treatments and researches of malignant tumors.