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宫颈环形电切术联合重组人干扰素α2b阴道泡腾胶囊对宫颈上皮内瘤变的疗效观察

Observation in effect of loop electrosurgical excision procedure combined with recombinant human interferon α2b vaginal effervescent capsules in the treatment of cervical intraepithelial neoplasia

    摘要
  • 摘要:
      目的   观察宫颈环形电切术(LEEP)联合重组人干扰素α2b阴道泡腾胶囊对宫颈上皮内瘤变(CIN)的临床疗效。
      方法   选取186例CIN患者作为研究对象，采用随机数字表法分为研究组和对照组，每组93例。对照组采用LEEP治疗，研究组采用LEEP联合重组人干扰素α2b阴道泡腾胶囊治疗。观察2组治疗前后的免疫功能指标、手术指标变化，比较2组治疗效果、复发率及并发症发生情况。
      结果   研究组CINⅠ级患者的阴道排液量少于对照组，创面愈合时间短于对照组，差异有统计学意义(P <0.05); 研究组CINⅡ级、Ⅲ级患者和全组患者的阴道排液量均少于对照组，阴道排液时间、创面愈合时间均短于对照组，差异有统计学意义(P <0.05)。治疗后，研究组CD4+、CD4+/CD8+水平均高于对照组, CD8+水平低于对照组，差异有统计学意义(P <0.05)。治疗后，研究组C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)水平低于对照组，白细胞介素-10(IL-10)水平高于对照组，差异有统计学意义(P <0.05)。研究组治疗总有效率(93.55%)高于对照组(79.57%), 术后复发率(2.15%)低于对照组(13.98%), 差异有统计学意义(P <0.05)。2组围术期并发症总发生率比较，差异无统计学意义(P >0.05)。
      结论   LEEP联合重组人干扰素α2b阴道泡腾胶囊治疗CIN能够有效调节机体免疫功能，提高临床疗效，降低术后复发风险。

     

    Abstract:
      Objective   To observe the clinical efficacy of loop electrosurgical excision procedure (LEEP) combined with recombinant human interferon α2b vaginal effervescent capsules in the treatment of cervical intraepithelial neoplasia (CIN).
      Methods   A total of 186 patients with CIN were selected as study objects, and were randomly divided into study group(n=93) and control group (n=93) according to random number table method. The control group was treated with LEEP, and the study group was treated with recombinant human interferon α2b vaginal effervescent capsules on the basis of the control group. The changes of immune function and operation indexes were observed before and after treatment, and the treatment effect, recurrence rate and complications were compared between the two groups.
      Results   The vaginal discharge volume of patients with CIN Ⅰ, Ⅱ and Ⅲ grade in the study group was less than that in the control group, and the wound healing time patients with CIN Ⅰ was shorter than that in the control group (P <0.05). Compared with the control group, the vaginal discharge volume of patients in the study group was less than that in the control group, vaginal discharge time and wound healing time of the study group were shorter than those in the control group (P <0.05). The levels of CD4+, CD4+/CD8+ in the study group after treatment were higher than those in the control group, and the level of CD8+ in the study group was lower than that in the control group (P <0.05). Compared with the control group, the levels of C-reactive protein (CRP) and tumor necrosis factor-α(TNF-α) in the study group were lower, and the level of IL-10 was higher (P <0.05). The total effective rate of the study group was significantly higher than that of the control group (93.55% versus 79.57%, P <0.05), and the postoperative recurrence rate was significantly lower than that of thecontrol group (2.15% versus 13.98%, P <0.05). There was no significant difference in the total incidence of perioperative complications between the two groups (P >0.05).
      Conclusion   LEEP combined with recombinant human interferon α2b vaginal effervescent capsules in the treatment of CIN can effectively regulate the immune function, improve the clinical efficacy and reduce the risk of postoperative recurrence.

     

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