Research progress of exocrine in septic organ dysfunction
-
摘要: 外泌体是一种由活细胞分泌的纳米级膜性囊泡，包含核酸、蛋白质和脂质等活性分子，可以促进细胞间的信号传递。近期研究表明，脓毒症期间的外泌体中富含细胞因子和损伤相关模式分子（DAMPs），在促进炎症反应及介导脓毒症期间的器官功能障碍中发挥着重要作用。本文对外泌体在脓毒症中的调节机制以及在继发性多器官功能障碍中的作用进行综述。Abstract: Exosomes are nanometer-sized membranous vesicles released by living cells. Exosomes are carriers of several active molecules such as nucleic acids, proteins and lipids, which can promote signal transmission between cells. Recent studies have shown that exosomes during sepsis are rich in cytokines and damage associated molecular patterns (DAMPs), which play important roles in promoting inflammation and mediating organ dysfunction during sepsis. This paper summarized the regulation mechanism of exosomes in sepsis and its roles in secondary multiple organ dysfunction.
-
Keywords:
- exosomes /
- sepsis /
- organ dysfunction /
- inflammatory response
-
-
[1] KALLURI R, LEBLEU V S. The biology, function, and biomedical applications of exosomes[J]. Science, 2020, 367(6478): 65-71. http://med.wanfangdata.com.cn/Paper/Detail/PeriodicalPaper_PM32029601
[2] PEGTEL D M, GOULD S J. Exosomes[J]. Annu Rev Biochem, 2019, 88: 487-514. doi: 10.1146/annurev-biochem-013118-111902
[3] 韩杰, 葛安, 马晓霞, 等. 外泌体提取及保存技术研究进展[J]. 中国细胞生物学学报, 2021(2): 451-459. https://kns.cnki.net/kcms/detail/detail.aspx?dbcode=CJFD&dbname=CJFDLAST2021&filename=XBZZ202102022&v=BOBRxlXcSbJ7trz4V8PbWHM7FGesPrK6gmnI50iDry%25mmd2Bp2xjrj7pppG6YXXBNux%25mmd2F8 [4] 晏飞利, 李慧, 李春红. 巨噬细胞来源外泌体的提取与鉴定[J]. 西南医科大学学报, 2020, 43(3): 238-241. doi: 10.3969/j.issn.2096-3351.2020.03.006 [5] THÉRY C, WITWER K W, AIKAWA E, et al. Minimal information for studies of extracellular vesicles 2018(MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines[J]. J Extracell Vesicles, 2018, 7(1): 153-159. http://www.ncbi.nlm.nih.gov/pubmed/30637094
[6] ZHANG Y, BI J, HUANG J, et al. Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications[J]. Int J Nanomedicine, 2020, 15: 6917-6934. doi: 10.2147/IJN.S264498
[7] HUANG M, CAI S, SU J. The pathogenesis of Sepsis and potential therapeutic targets[J]. Int J Mol Sci, 2019, 20(21): 5376. doi: 10.3390/ijms20215376
[8] ESSANDOH K, YANG L, WANG X, et al. Blockade of exosome generation with GW4869 dampens the sepsis-induced inflammation and cardiac dysfunction[J]. Biochim Biophys Acta, 2015, 1852(11): 2362-2371. doi: 10.1016/j.bbadis.2015.08.010
[9] 郭媛媛, 尤学红, 丁学华, 等. 上皮细胞来源的外泌体通过TLR/MyD88信号通路促进BCG诱导的巨噬细胞的炎症反应[J]. 免疫学杂志, 2020(3): 229-234. https://www.cnki.com.cn/Article/CJFDTOTAL-MYXZ202003009.htm [10] CAO L, XU H, WANG G, et al. Extracellular vesicles derived from bone marrow mesenchymal stem cells attenuate dextran sodium sulfate-induced ulcerative colitis by promoting M2 macrophage polarization[J]. Int Immunopharmacol, 2019, 72: 264-274. doi: 10.1016/j.intimp.2019.04.020
[11] 傅小媚, 霍然, 邓赛, 等. 脂多糖刺激的骨髓间充质干细胞来源外泌体改善小鼠心肌梗死后炎症和纤维化[J]. 中国临床药理学与治疗学, 2019, 24(8): 841-851. https://www.cnki.com.cn/Article/CJFDTOTAL-YLZL201908002.htm [12] BHATNAGAR S, SHINAGAWA K, CASTELLINO F J, et al. Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo[J]. Blood, 2007, 110(9): 3234-3244. doi: 10.1182/blood-2007-03-079152
[13] SMITH V L, CHENG Y, BRYANT B R, et al. Exosomes function in antigen presentation during an in vivo Mycobacterium tuberculosis infection[J]. Sci Rep, 2017, 7: 43578. doi: 10.1038/srep43578
[14] YE S B, LI Z L, LUO D H, et al. Tumor-derived exosomes promote tumor progression and T-cell dysfunction through the regulation of enriched exosomal microRNAs in human nasopharyngeal carcinoma[J]. Oncotarget, 2014, 5(14): 5439-5452. doi: 10.18632/oncotarget.2118
[15] WU S C, YANG J C, RAU C S, et al. Profiling circulating microRNA expression in experimental Sepsis using cecal ligation and puncture[J]. PLoS One, 2013, 8(10): e77936. doi: 10.1371/journal.pone.0077936
[16] REITHMAIR M, BUSCHMANN D, MÄRTE M, et al. Cellular and extracellular miRNAs are blood-compartment-specific diagnostic targets in Sepsis[J]. J Cell Mol Med, 2017, 21(10): 2403-2411. doi: 10.1111/jcmm.13162
[17] RAEVEN P, ZIPPERLE J, DRECHSLER S. Extracellular vesicles as markers and mediators in Sepsis[J]. Theranostics, 2018, 8(12): 3348-3365. doi: 10.7150/thno.23453
[18] BOURDONNAY E, ZASŁONA Z, PENKE L R, et al. Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling[J]. J Exp Med, 2015, 212(5): 729-742. doi: 10.1084/jem.20141675
[19] ZHOU Y, LI P, GOODWIN A J, et al. Exosomes from endothelial progenitor cells improve the outcome of a murine model of Sepsis[J]. Mol Ther, 2018, 26(5): 1375-1384. doi: 10.1016/j.ymthe.2018.02.020
[20] 张国虎, 李友军, 夏金明, 等. NO诱导富含miR-126的胎盘间充质干细胞外泌体治疗大鼠脓毒症[J]. 安徽医科大学学报, 2019(6): 918-925. https://www.cnki.com.cn/Article/CJFDTOTAL-YIKE201906017.htm [21] WANG J, WANG H, ZHU R, et al. Anti-inflammatory activity of curcumin-loaded solid lipid nanoparticles in IL-1β transgenic mice subjected to the lipopolysaccharide-induced Sepsis[J]. Biomaterials, 2015, 53: 475-483. doi: 10.1016/j.biomaterials.2015.02.116
[22] CZEMPIK P F, PLUTA M P, KRZYCH Ł J. Sepsis-associated brain dysfunction: a review of current literature[J]. Int J Environ Res Public Health, 2020, 17(16): 5852. doi: 10.3390/ijerph17165852
[23] BALUSU S, VAN WONTERGHEM E, DE RYCKE R, et al. Identification of a novel mechanism of blood-brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles[J]. EMBO Mol Med, 2016, 8(10): 1162-1183. doi: 10.15252/emmm.201606271
[24] PARK E J, APPIAH M G, MYINT P K, et al. Exosomes in Sepsis and Inflammatory Tissue Injury[J]. Curr Pharm Des, 2019, 25(42): 4486-4495. http://www.researchgate.net/publication/336730258_Exosomes_in_Sepsis_Diagnosis_and_Treatment
[25] LI J J, WANG B, KODALI M C, et al. In vivo evidence for the contribution of peripheral circulating inflammatory exosomes to neuroinflammation[J]. J Neuroinflammation, 2018, 15(1): 8. doi: 10.1186/s12974-017-1038-8
[26] REN C, YAO R Q, ZHANG H, et al. Sepsis-associated encephalopathy: a vicious cycle of immunosuppression[J]. J Neuroinflammation, 2020, 17(1): 14. doi: 10.1186/s12974-020-1701-3
[27] 陈文涛, 曾庆铨, 林庆斌, 等. 脓毒症患者血清外泌体对脓毒症大鼠急性肺损伤的影响[J]. 西部医学, 2020, 32(6): 818-822. doi: 10.3969/j.issn.1672-3511.2020.06.007 [28] JIANG K, YANG J, GUO S, et al. Peripheral circulating exosome-mediated delivery of miR-155 as a novel mechanism for acute lung inflammation[J]. Mol Ther, 2019, 27(10): 1758-1771. doi: 10.1016/j.ymthe.2019.07.003
[29] LIU A, ZHANG X, HE H, et al. Therapeutic potential of mesenchymal stem/stromal cell-derived secretome and vesicles for lung injury and disease[J]. Expert Opin Biol Ther, 2020, 20(2): 125-140. doi: 10.1080/14712598.2020.1689954
[30] ZHOU Y, LI P, GOODWIN A J, et al. Exosomes from endothelial progenitor cells improve outcomes of the lipopolysaccharide-induced acute lung injury[J]. Crit Care, 2019, 23(1): 44. doi: 10.1186/s13054-019-2339-3
[31] LI J, DENG X Q, JI X L, et al. Mesenchymal stem cell exosomes reverse acute lung injury through Nrf-2/ARE and NF-κB signaling pathways[J]. PeerJ, 2020, 8: e9928. doi: 10.7717/peerj.9928
[32] JANISZEWSKI M, DO CARMO A O, PEDRO M A, et al. Platelet-derived exosomes of septic individuals possess proapoptotic NAD(P)H oxidase activity: a novel vascular redox pathway[J]. Crit Care Med, 2004, 32(3): 818-825. doi: 10.1097/01.CCM.0000114829.17746.19
[33] HAILESELASSIE B, SU E, POZIOS I, et al. Myocardial oxidative stress correlates with left ventricular dysfunction on strain echocardiography in a rodent model of Sepsis[J]. Intensive Care Med Exp, 2017, 5(1): 21. doi: 10.1186/s40635-017-0134-5
[34] KERVADEC A, BELLAMY V, EL HARANE N, et al. Cardiovascular progenitor-derived extracellular vesicles recapitulate the beneficial effects of their parent cells in the treatment of chronic heart failure[J]. J Heart Lung Transplant, 2016, 35(6): 795-807. doi: 10.1016/j.healun.2016.01.013
[35] QIAO L, HU S Q, LIU S Y, et al. microRNA-21-5p dysregulation in exosomes derived from heart failure patients impairs regenerative potential[J]. J Clin Investig, 2019, 129(6): 2237-2250. doi: 10.1172/JCI123135
[36] WANG G, JIN S, LING X, et al. Proteomic profiling of LPS-induced macrophage-derived exosomes indicates their involvement in acute liver injury[J]. Proteomics, 2019, 19(3): e1800274. doi: 10.1002/pmic.201800274
[37] RAMANATHAN S, DOUGLAS S R, ALEXANDER G M, et al. Exosome microRNA signatures in patients with complex regional pain syndrome undergoing plasma exchange[J]. J Transl Med, 2019, 17(1): 81. http://www.ncbi.nlm.nih.gov/pubmed/30871575
[38] SHEN Y, MALIK S A, AMIR M, et al. Decreased hepatocyte autophagy leads to synergistic IL-1β and TNF mouse liver injury and inflammation[J]. Hepatology, 2020, 72(2): 595-608. doi: 10.1002/hep.31209
[39] CHEN L, YAO X, YAO H, et al. Exosomal miR-103-3p from LPS-activated THP-1 macrophage contributes to the activation of hepatic stellate cells[J]. FASEB J, 2020, 34(4): 5178-5192. doi: 10.1096/fj.201902307RRR
[40] LV L L, FENG Y, WU M, et al. Exosomal miRNA-19b-3p of tubular epithelial cells promotes M1 macrophage activation in kidney injury[J]. Cell Death Differ, 2020, 27(1): 210-226. doi: 10.1038/s41418-019-0349-y
[41] SONODA H, LEE B R, PARK K H, et al. miRNA profiling of urinary exosomes to assess the progression of acute kidney injury[J]. Sci Rep, 2019, 9(1): 4692. doi: 10.1038/s41598-019-40747-8
[42] APPIAH M G, PARK E J, DARKWAH S, et al. Intestinal Epithelium-Derived Luminally Released Extracellular Vesicles in Sepsis Exhibit the Ability to Suppress TNF-a and IL-17A Expression in Mucosal Inflammation[J]. Int J Mol Sci, 2020, 21(22): 210-226. http://www.researchgate.net/publication/346805517_Intestinal_Epithelium-Derived_Luminally_Released_Extracellular_Vesicles_in_Sepsis_Exhibit_the_Ability_to_Suppress_TNF-a_and_IL-17A_Expression_in_Mucosal_Inflammation/download
[43] PARK K S, LEE J, LEE C, et al. Sepsis-like systemic inflammation induced by nano-sized extracellular vesicles from feces[J]. Front Microbiol, 2018, 9: 1735. http://www.ncbi.nlm.nih.gov/pubmed/30131776
[44] HAAK B W, WIERSINGA W J. The role of the gut microbiota in Sepsis[J]. Lancet Gastroenterol Hepatol, 2017, 2(2): 135-143. http://europepmc.org/abstract/MED/28403983
[45] MURAO A, BRENNER M, AZIZ M, et al. Exosomes in Sepsis[J]. Front Immunol, 2020, 11: 2140. http://www.researchgate.net/publication/344265963_Exosomes_in_Sepsis
-
期刊类型引用(0)
其他类型引用(1)
计量
- 文章访问数: 378
- HTML全文浏览量: 188
- PDF下载量: 45
- 被引次数: 1
下载:
苏公网安备 32100302010246号
