糖尿病合并非小细胞肺癌的临床特征及发病危险因素分析

刘荣凤; 崔彦芝; 徐志宏; 张玲玲

doi:10.7619/jcmp.20211239

糖尿病合并非小细胞肺癌的临床特征及发病危险因素分析

Analysis of clinical features of diabetes mellitus complicated with non-small cell lung cancer and its risk factors

摘要

摘要:
目的分析糖尿病合并非小细胞肺癌的临床特征及发病危险因素。
方法前瞻性选取糖尿病合并非小细胞肺癌患者62例为合并组，另选取同期收治的单纯非小细胞肺癌患者161例为对照组。比较2组基线资料、临床特征及其他相关资料; 分析可能诱发糖尿病合并非小细胞肺癌的危险因素。
结果合并组胸背部疼痛发生率以及空腹血糖(FPG)、甘油三酯(TG)高于对照组，高密度脂蛋白胆固醇(HDL-C)低于对照组，差异有统计学意义(P < 0.05); 吸烟史、呼吸系统基础疾病均是糖尿病合并非小细胞肺癌发病的危险因素(OR>1, P < 0.05)。
结论糖尿病合并非小细胞肺癌临床发病无特异性表现，病理分型中腺癌占比最高，且多呈低分化。吸烟史、呼吸系统基础疾病是诱发糖尿病合并非小细胞肺癌发病的危险因素。

Abstract:
Objective To analyze the clinical features of diabetes mellitus combined with non-small cell lung cancer and its risk factors.
Methods A total of 62 patients with diabetes mellitus complicated with non-small cell lung cancer were prospectively selected as combined group, and 161 patients with simple non-small cell lung cancer were selected as control group during the same period. Baseline data, clinical features and other relevant data were compared between the two groups; the risk factors of diabetes mellitus complicated with non-small cell lung cancer were analyzed.
Results The incidence of chest and back pain, fasting blood glucose (FPG) and triglyceride (TG) in the combined group were significantly higher than those in the control group, while high density lipoprotein cholesterol (HDL-C) was significantly lower than that in the control group (P < 0.05). Smoking history and basic diseases of respiratory system were risk factors for diabetes mellitus combined with non-small cell lung cancer (OR>1, P < 0.05).
Conclusion Diabetes mellitus combined with non-small cell lung cancer has no specific performance in clinical attack, and adenocarcinoma accounted for the highest proportion of pathological types, and most of them are poorly differentiated. Smoking history and basic diseases of respiratory system are risk factors for diabetes mellitus complicated with non-small cell lung cancer.

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