不同疾病组成的自身免疫性多内分泌腺综合征Ⅱ型3例

Three cases of type Ⅱ autoimmune polyendocrine syndrome with different diseases composition

摘要:
目的分析自身免疫性多内分泌腺病综合征（APS）患者临床特点。
方法对符合APS Ⅱ型标准的3例患者的自身免疫性疾病的构成、主要临床表现进行分析。
结果本文3例患者发病时分别表现出皮质功能减退，胰岛功能衰竭，甲状腺机能减退伴低钙血症等不同症状，病程中先后累及多个不同内分泌腺和非内分泌器官。
结论 APS发病隐匿，从一个腺体疾病发展到另一个或多个腺体疾病的时间存在不确定性，易被漏诊而耽误治疗。在诊断时，需常规筛查相关抗体并长期随访，以及早诊断及治疗。

Abstract:
Objective To analyze the clinical characteristics of patients with autoimmune polyendocrine syndrome (APS).
Methods The composition and main clinical manifestations of autoimmune diseases in 3 patients with APS Ⅱ were analyzed.
Results Three patients presented with different symptoms of cortical hypofunction, islet failure, hypothyroidism with hypocalcemia. Multiple endocrine glands and non-endocrine organs were involved in the course of the disease.
Conclusion The onset of APS is insidious, and the time from one gland disease to another or more gland diseases is uncertain, which is easy to be missed in diagnosis and delayed in treatment. At the time of diagnosis, routine screening and long-term follow-up are needed for early diagnosis and treatment.