肥胖人群消化道黏膜损伤机制的研究进展

徐晨皓; 刘昕

doi:10.7619/jcmp.20211707

肥胖人群消化道黏膜损伤机制的研究进展

徐晨皓¹,
刘昕^{2, 3, ,}

1.
扬州大学医学院, 江苏扬州, 225009
2.
江苏省苏北人民医院/扬州大学附属苏北医院麻醉科, 江苏扬州, 225000
3.
徐州医科大学临床医学院, 江苏徐州, 221018

基金项目:

徐州医科大学一流专业建设专项课题 Xjyylzx201901

详细信息

通讯作者:
刘昕, E-mail: 615389622@163.com

中图分类号: R57;R589.2
计量
- 文章访问数: 277
- HTML全文浏览量: 151
- PDF下载量: 20
出版历程
- 收稿日期: 2021-04-21
- 网络出版日期: 2021-10-19
- 发布日期: 2021-09-27

Research progress on mechanism of digestive tract mucosal injury in obese population

XU Chenhao¹,
LIU Xin^{2, 3, ,}

1.
School of Medicine, Yangzhou University, Yangzhou, Jiangsu, 225009
2.
Department of Anesthesiology, Subei People′s Hospital, Subei Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, 225000
3.
School of Clinical Medicine of Xuzhou Medical University, Xuzhou, Jiangsu, 221018

摘要

摘要: 肥胖会引发很多健康问题，其中肥胖人群的消化道黏膜损伤问题尤其值得重视。消化道黏膜损伤的伴发和进展，不仅严重影响肥胖人群的日常生活质量，还会造成胃癌等严重疾病的高发。现将肥胖人群消化道黏膜损伤发病机制的研究进展综述如下，以期为相关疾病的治疗与干预提供更充分的理论依据。
- 肥胖症 /
- 消化道 /
- 黏膜损伤 /
- 胃肠道 /
- 食管
Abstract: Obesity can give rise to various health problems, of which the gastrointestinal mucosal injury in obese people is worth of attention. The complications and progression of gastrointestinal mucosal injury not only seriously affect the daily life quality of obese people, but also cause high incidence of gastric cancer and other serious diseases. This article reviewed the research progress on the pathogenesis of digestive tract mucosal injury in obese population, in order to provide a more sufficient theoretical basis for clinical practice.
- obesity /
- gastrointestinal tract /
- mucosal injury /
- gastrointestinal tract /
- esophagus

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参考文献(39)

[1]	WANG Y, XUE H, SUN M, et al. Prevention and control of obesity in China[J]. Lancet Glob Health, 2019, 7(9): e1166-e1167. doi: 10.1016/S2214-109X(19)30276-1
[2]	ANSARI S, HABOUBI H, HABOUBI N. Adult obesity complications: challenges and clinical impact[J]. Ther Adv Endocrinol Metab, 2020, 11: 2042018820934955. http://www.researchgate.net/publication/342359235_Adult_obesity_complications_challenges_and_clinical_impact
[3]	SONG M, CHOI J Y, YANG J J, et al. Obesity at adolescence and gastric cancer risk[J]. Cancer Causes Control, 2015, 26(2): 247-256. doi: 10.1007/s10552-014-0506-z
[4]	BHAT S, VARGHESE C, CARSON D A, et al. Gastric dysrhythmia in gastroesophageal reflux disease: a systematic review and meta-analysis[J]. Esophagus, 2021, 18(3): 425-435. doi: 10.1007/s10388-021-00820-6
[5]	RICHTER J E, RUBENSTEIN J H. Presentation and epidemiology of gastroesophageal reflux disease[J]. Gastroenterology, 2018, 154(2): 267-276. doi: 10.1053/j.gastro.2017.07.045
[6]	朱乾坤, 任海洋, 李小东, 等. 合并肥胖的胃食管反流病外科策略选择[J]. 世界华人消化杂志, 2020, 28(2): 43-49. https://www.cnki.com.cn/Article/CJFDTOTAL-XXHB202002001.htm
[7]	凯赛尔·艾则孜, 艾克拜尔·艾力, 克力木·阿不都热依木. 胃食管反流病与肥胖症及其并发症的相关性研究进展[J]. 中华胃食管反流病电子杂志, 2016, 3(4): 187-189. https://www.cnki.com.cn/Article/CJFDTOTAL-SDFL201604013.htm
[8]	买买提·依斯热依力, 艾克拜尔·艾力, 吾布力卡斯木·吾拉木, 等. 饮食诱导小鼠肥胖模型中胃食管黏膜的变化研究[J]. 中华胃食管反流病电子杂志, 2018, 5(1): 10-14. https://www.cnki.com.cn/Article/CJFDTOTAL-SDFL201801003.htm
[9]	TOBEY N A, CARSON J L, ALKIEK R A, et al. Dilated intercellular spaces: a morphological feature of acid reflux: damaged human esophageal epithelium[J]. Gastroenterology, 1996, 111(5): 1200-1205. doi: 10.1053/gast.1996.v111.pm8898633
[10]	BJÖRKMAN E V C, EDEBO A, OLTEAN M, et al. Esophageal barrier function and tight junction expression in healthy subjects and patients with gastroesophageal reflux disease: functionality of esophageal mucosa exposed to bile salt and trypsin in vitro[J]. Scand J Gastroenterol, 2013, 48(10): 1118-1126. doi: 10.3109/00365521.2013.828772
[11]	林燕芳, 柳刚, 王雯. 核因子E2相关因子2在胃食管反流病食管黏膜损伤中的作用[J]. 国际消化病杂志, 2018, 38(6): 370-373. doi: 10.3969/j.issn.1673-534X.2018.06.005
[12]	HAASE C L, SCHNECKE V, ERIKSEN K T. BMI and risk of obesity-related outcomes in a large UK population-representative cohort: a CPRD/HES study[A]. 26th European Congress on Obesity, Glasgow, 2019[C]. Scotland: European Journal of Clinical Nutrition, 2019: 32.
[13]	马颖. 肥胖与高血压、高脂血症、高血糖的相关性探析[J]. 中国实用医药, 2013, 8(25): 240-241. doi: 10.3969/j.issn.1673-7555.2013.25.193
[14]	TAYLOR R. Calorie restriction for long-term remission of type 2 diabetes[J]. Clin Med: Lond, 2019, 19(1): 37-42. http://www.onacademic.com/detail/journal_1000041716714299_8433.html
[15]	THAISS C A, LEVY M, GROSHEVA I, et al. Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection[J]. Science, 2018, 359(6382): 1376-1383. doi: 10.1126/science.aar3318
[16]	JESSURUN J. Helicobacter pylori: an evolutionary perspective[J]. Histopathology, 2021, 78(1): 39-47. doi: 10.1111/his.14245
[17]	谢勇, 吕农华, 陈江, 等. 幽门螺杆菌长期感染对胃粘膜的影响[J]. 中华消化内镜杂志, 2001, 18(4): 204-206. doi: 10.3760/cma.j.issn.1007-5232.2001.04.004
[18]	徐肇敏, 张志宏, 陈戴融, 等. 幽门螺杆菌破坏胃粘膜屏障的研究[J]. 中华内科杂志, 1995, 34(9): 603-605. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHNK509.010.htm
[19]	SUKI M, LEIBOVICI WEISSMAN Y, BOLTIN D, et al. Helicobacter pylori infection is positively associated with an increased BMI, irrespective of socioeconomic status and other confounders: a cohort study[J]. Eur J Gastroenterol Hepatol, 2018, 30(2): 143-148. doi: 10.1097/MEG.0000000000001014
[20]	XU X L, LI W D, QIN L, et al. Relationship between Helicobacter pylori infection and obesity in Chinese adults: a systematic review with meta-analysis[J]. PLoS One, 2019, 14(9): e0221076. doi: 10.1371/journal.pone.0221076
[21]	ZHANG Y, DU T T, CHEN X, et al. Association between Helicobacter pylori infection and overweight or obesity in a Chinese population[J]. J Infect Dev Ctries, 2015, 9(9): 945-953. doi: 10.3855/jidc.6035
[22]	万政策, 胡柳, 胡梅, 等. 体检人群幽门螺杆菌感染与超重、肥胖的相关性研究[J]. 中华健康管理学杂志, 2018, 12(4): 327-331. doi: 10.3760/cma.j.issn.1674-0815.2018.04.008
[23]	杨玉梅, 刘玉萍, 王林, 等. 成都地区居民幽门螺杆菌感染现状及危险因素分析[J]. 现代预防医学, 2020, 47(17): 3220-3224. https://www.cnki.com.cn/Article/CJFDTOTAL-XDYF202017040.htm
[24]	WU Q Q, QIN K, WANG Y J. Central obesity is associated with Helicobacter pylori infection: a large-scale cross-sectional retrospective study in West China[J]. Int J Diabetes Dev Countr, 2020, 40(1): 52-60. doi: 10.1007/s13410-019-00765-8
[25]	CHEN L W, KUO S F, CHEN C H, et al. A community-based study on the association between Helicobacter pylori Infection and obesity[J]. Sci Rep, 2018, 8(1): 10746. doi: 10.1038/s41598-018-28792-1
[26]	杨鑫. 肥胖对幽门螺杆菌感染后胃黏膜炎症与STAT3表达的影响[D]. 青岛: 青岛大学, 2020.
[27]	张勍, 成祥军. 肠道微生物环境对大学生机体免疫及肥胖的影响[J]. 山东农业大学学报: 自然科学版, 2018, 49(1): 175-180. doi: 10.3969/j.issn.1000-2324.2018.01.036
[28]	PARKS B W, NAM E, ORG E, et al. Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice[J]. Cell Metab, 2013, 17(1): 141-152. doi: 10.1016/j.cmet.2012.12.007
[29]	HAMILTON M K, BOUDRY G, LEMAY D G, et al. Changes in intestinal barrier function and gut microbiota in high-fat diet-fed rats are dynamic and region dependent[J]. Am J Physiol Gastrointest Liver Physiol, 2015, 308(10): G840-G851. doi: 10.1152/ajpgi.00029.2015
[30]	BRUN P, CASTAGLIUOLO I, LEO V D, et al. Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis[J]. Am J Physiol Gastrointest Liver Physiol, 2007, 292(2): G518-G525. doi: 10.1152/ajpgi.00024.2006
[31]	刘航, 赵庆杰, 徐伟. 信号转导及转录激活因子3抑制剂研究进展[J]. 药学实践杂志, 2021, 39(1): 4-8. https://www.cnki.com.cn/Article/CJFDTOTAL-YXSJ202101003.htm
[32]	KANDA J Y, MATSUO K, SUZUKI T, et al. Association between obesity and the risk of malignant lymphoma in Japanese: a case-control study[J]. Int J Cancer, 2010, 126(10): 2416-2425. http://www.onacademic.com/detail/journal_1000033848152710_5504.html
[33]	LI Q, ZHANG J, ZHOU Y N, et al. Obesity and gastric cancer[J]. Front Biosci Landmark Ed, 2012, 17: 2383-2390. doi: 10.2741/4059
[34]	ARITA S, OGAWA T, MURAKAMI Y, et al. Dietary fat-accelerating leptin signaling promotes protumorigenic gastric environment in mice[J]. Nutrients, 2019, 11(9): 2127. doi: 10.3390/nu11092127
[35]	TALLEY N J, HOWELL S, POULTON R. Obesity and chronic gastrointestinal tract symptoms in young adults: a birth cohort study[J]. Am J Gastroenterol, 2004, 99(9): 1807-1814. doi: 10.1111/j.1572-0241.2004.30388.x
[36]	KRISTO I, PAIREDER M, JOMRICH G, et al. Silent gastroesophageal reflux disease in patients with morbid obesity prior to primary metabolic surgery[J]. Obes Surg, 2020, 30(12): 4885-4891. doi: 10.1007/s11695-020-04959-6
[37]	皮尔地瓦斯·麦麦提玉素甫, 艾克拜尔·艾力, 买买提·依斯热依力, 等. 腹腔镜胃底折叠术联合胃袖状切除术治疗肥胖合并胃食管反流病临床研究[J]. 中国实用外科杂志, 2020, 40(4): 437-440, 443. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGWK202004022.htm
[38]	FEAKINS R M. Obesity and metabolic syndrome: pathological effects on the gastrointestinal tract[J]. Histopathology, 2016, 68(5): 630-640. doi: 10.1111/his.12907
[39]	LINDKVIST B, JOHANSEN D, STOCKS T, et al. Metabolic risk factors for esophageal squamous cell carcinoma and adenocarcinoma: a prospective study of 580, 000 subjects within the Me-Can project[J]. BMC Cancer, 2014, 14: 103. doi: 10.1186/1471-2407-14-103

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