高级检索

核苷酸结合寡聚化结构域样受体蛋白3炎症小体对冠状动脉支架植入术后支架内再狭窄的影响

Effect of nucleotide binding oligomerization domain-like receptor protein 3 inflammasome on in-stent restenosis after coronary stent implantation

    摘要
  • 摘要:
      目的  探讨核苷酸结合寡聚化结构域样受体蛋白3（NLRP3）炎症小体的表达水平与冠状动脉支架植入术后支架内再狭窄（ISR）的相关关系。
      方法  选取住院治疗并成功行初次经皮冠状动脉介入治疗（PCI）术的患者150例，术前、术后24 h应用免疫印迹法定量分析NLRP3。1年后复查冠状动脉造影，根据ISR诊断标准将患者分为ISR组（n=22）与对照组（n=128），分析NLRP3表达水平与ISR严重程度的相关关系。
      结果  1年后复查时，ISR组NLRP3表达水平较对照组升高，差异有统计学意义（P < 0.05），且在一定范围内随着ISR严重程度的升高，NLRP3表达水平可逐渐增高，二者存在简单线性正相关关系（r=0.862，P=0.001）。
      结论  NLRP3表达水平与冠状动脉ISR严重程度呈正相关。

     

    Abstract:
      Objective  To investigate the relationship between the expression of inflammatory bodies nucleotide binding oligomerization domain-like receptor protein 3 (NLRP3) and in-stent restenosis(ISR) after coronary stent implantation.
      Methods  A total of 150 hospitalized patients who successfully underwent primary percutaneous coronary intervention (PCI) were selected. NLRP3 was quantitatively analyzed by Western Blot before and 24 hours after PCI. Coronary angiography was reexamined one year later. According to ISR diagnostic criteria, they were divided into ISR group (n=22) and control group (n=128), and the correlation between the expression level of NLRP3 and the severity of ISR was analyzed.
      Results  One year later, the expression level of NLRP3 in the ISR group was significantly higher than that in the control group (P < 0.05), and the NLRP3 expression level was gradually increased with the increase of ISR severity within a certain range. They showed a simple linear positive correlation between NLRP3 and ISR severity (r=0.862, P=0.001).
      Conclusion  The expression level of NLRP3 is positively related to the severity of coronary ISR.

     

    • HTML全文
    • 参考文献(15)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回