Characteristics of electrical impedance tomography in healthy people and its normal range
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摘要:目的 探讨北京地区健康志愿者肺组织的电阻抗层析成像（EIT）测量值的正常范围。方法 采用分层抽样方法选取102例健康志愿者（男、女志愿者各51例），分别收集其坐位、仰卧位时平静呼吸和最大呼吸状态下的总阻抗（GI）和阻抗区域（ROI）。分析不同年龄、性别、体质量指数（BMI）和其他分层因素的阻抗值范围。结果 无论男性或女性，在最大呼吸状态下，GI和ROI值均高于平静呼吸状态；男性GI和ROI均高于女性（卧位平静呼吸状态下除外）。在4个ROI中，无论男性或女性，ROI2和ROI3占GI比率较高。结论 本研究测得了北京地区健康志愿者EIT的基础范围值，可作为EIT系统研究和临床使用的参考依据。Abstract:Objective To investigate the normal range of electrical impedance tomography (EIT) measurements in lung tissue of healthy volunteers in Beijing area.Methods A total of 102 healthy volunteers (51 males and 51 females) were selected by stratified sampling method, and global impedance (GI) as well as region of interest (ROI) were collected for calm breathing and maximum breathing in sitting and supine positions, respectively. Impedance ranges for age, sex, body mass index (BMI) and other stratified factors were analyzed.Results The GI and ROI of both males and females in maximal breathing state were higher than those in calm breathing state. The GI and ROI of males were higher than that of females (except in the decubitus position with calm breathing). In four ROIs, ROI2 and ROI3 accounted for higher proportions of GI in both males and females.Conclusion The basic range values of EIT in healthy volunteers in Beijing area are measured in this study, which can be used as a reference for EIT system research and clinical use.
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表 1 受检人群基线特征(x±s)
因素 受试者特征(n=102) 年龄/岁 43±21 性别 男 51 女 51 身高/m 1.65±0.08 体质量/kg 66.6±12.5 体质量指数/(kg/m2) 24±4 
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表 2 在不同呼吸条件下坐位和仰卧位受试者的肺总阻抗分布(x±s)
性别 坐位 卧位 平静呼吸状态 最大呼吸状态 平静呼吸状态 最大呼吸状态 男(n=51) 3 353 148±362 721 5 482 749±603 111 2 435 323±303 195 7 949 585±826 013 女(n=51) 1 910 780±230 168 4 227 808±522 656 2 685 644±30 117 4 500 566±496 294
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表 3 男性在不同体位和呼吸状态下监测EIT时各区域阻抗值(x±s)
体位 ROI1 ROI2 ROI3 ROI4 坐位 平静呼吸状态 329 333±35 865 1 388 769±151 770 1 486 407±157 902 405 268±37 318 占GI比率/% 9.2 39.3 42.0 9.1 最大呼吸状态 395 016±43 108 2 209 368±234 606 2 730 902±249 224 4 999 655±53 933 占GI比率/% 6.5 39.1 44.0 10.4 P 0.134 0.033 0.041 0.361 卧位 平静呼吸状态 315 780±40 612 1 144 899±152 959 998 874±117 619 270 181±34 262 占GI比率/% 12.2 42.2 35.2 10.4 平静呼吸状态 858 484±102 857 3 750 633±396 174 3 256 553 ±366 921 841 108 ±99 098 占GI比率/% 12.1 43.3 36.1 8.5 P 0.011 0.027 0.007 0.009 GI: 总阻抗; ROI: 阻抗区域。
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表 4 女性在不同体位和呼吸状态下监测EIT时各区域阻抗值(x±s)
体位 ROI1 ROI2 ROI3 ROI4 坐位 平静呼吸状态 329 333±35 865 1 388 769±151 770 1 486 407±157 902 405 268±37 318 占GI比率/% 9.2 39.3 42.0 9.1 最大呼吸状态 406 436±39 053 1 395 080±164 926 2 136 829±219 043 450 035±42 412 占GI比率/% 9.6 36.1 42.4 11.9 P 0.047 0.549 0.039 0.233 卧位 平静呼吸状态 204 920±25 017 1 130 797±131 072 1 283 676±125 979 239 077±24 757 占GI比率/% 10.8 40.6 38.1 10.5 最大呼吸状态 532 561±52 052 1 783 757±203 119 1 833 984 ±188 812 556 775±52 990 占GI比率/% 11.4 42.5 37.8 8.3 P 0.008 0.032 0.045 0.015 GI: 总阻抗; ROI: 阻抗区域。
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