Correlation of serum uric acid and fasting blood glucose with elasticity of large artery
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摘要:目的 探讨血尿酸和空腹血糖(FBG)与大动脉弹性的相关性。方法 选取健康体检的100例志愿者为研究对象，将其分为血尿酸正常组30例与异常组70例，再根据FBG水平分为正常组30例、调节受损组40例和糖尿病组30例。检测患者肱-踝脉搏波传导速度(ba PWV)和肱踝指数(ABI)值，采用多因素Logistic回归分析高尿酸血症的危险因素, Pearson检验分析血尿酸、FBG与大动脉弹性的相关性。结果 血尿酸异常组高血压和糖尿病患者占比增大，ABI值、甘油三酯(TG)、低密度脂蛋白(LDL-C)、FBG和baPWV均升高，但体质量指数(BMI)降低，差异有统计学意义(P＜0.05)。Logistics回归分析显示, BMI、高血压、TG、FBG、baPWV和ABI是高尿酸血症的独立危险因素(P＜0.05)。调节受损组和糖尿病组患者腰臀比、脉率、总胆固醇(TC)、LDL-C、FBG以及餐后2 h血糖水平均上升，差异有统计学意义(P＜0.05)。Pearson检验显示，血尿酸与FBG呈正相关，与baPWV和ABI呈负相关(P＜0.05)。结论 血尿酸和FBG与大动脉弹性具有密切关系，血尿酸与FBG呈正相关，与大动脉弹性呈负相关。
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关键词:
- 血尿酸 /
- 空腹血糖 /
- 大动脉弹性 /
- Logistic回归分析 /
- Pearson检验
Abstract:Objective To explore the correlation of serum uric acid and fasting blood glucose(FBG) with the elasticity of large artery.Methods A total of 100 healthy people who underwent physical examinations were selected as study subjects, and were divided into normal uric acid group (n=30) and abnormal group (n=70), and they were divided into normal group (n=30), impaired regulation group (n=40) and diabetic group (n=30) according to the level of FBG. The brachial-ankle pulse wave velocity (ba PWV) and brachial-ankle index (ABI) value were detected. Multivariate Logistic regression analysis was used to screen the factors affecting hyperuricemia, and Pearson test was used to analyze the relationship of serum uric acid and FBG with the elasticity of large artery.Results The proportions of patients with hypertension and diabetes, ABI, triglyceride (TG), low density lipoprotein (LDL-C), FBG and baPWV levels in the abnormal group were significantly increased than the normal group, but body mass index (BMI) decreased (P < 0.05). Logistics regression analysis showed that BMI, hypertension, TG, FBG, baPWV and ABI were the independent risk factors of hyperuricemia (P < 0.05). The waist-to-hip ratio, pulse rate, total cholesterol (TC), LDL-C, FBG and 2 h postprandial blood glucose level in impaired regulation group and diabetic group were significantly increased (P < 0.05). Pearson test showed that serum uric acid was positively correlated with FBG, and negatively correlated with baPWV and ABI (P < 0.05).Conclusion There are close relationships of serum uric acid and FBG with elasticity of the aorta, serum uric acid is positively correlated with FBG and negatively correlated with elasticity of the large artery. -
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表 1 2组一般资料比较(x±s)[n(%)]
指标 尿酸正常组(n=30) 尿酸异常组(n=70) 男 10(33.34) 25(35.71) 年龄/岁 40.12±5.26 40.34±5.25 BMI/(kg/m2) 28.13±3.01 22.56±3.15* 高血压 16(53.34) 21(30.00) 糖尿病 15(50.00) 20(28.57) TC/(mmol/L) 5.39±0.42 5.42±0.26 TG/(mmol/L) 1.68±0.42 1.75±0.16* HDL-C/(mmol/L) 1.50±0.46 1.42±0.59 LDL-C/(mmol/L) 2.04±0.49 3.01±0.59* FBG/(mmol/L) 5.40±0.32 6.18±0.65* baPWV/(cm/s) 1 275.80±80.00 1 782.00±82.00* ABI 8.59±2.34 12.45±1.56* BMI: 体质量指数; TC: 总胆固醇; TG: 甘油三酯; LDL-C: 低密度脂蛋白胆固醇; HDL-C: 高密度脂蛋白胆固醇; FBG: 空腹血糖; baPWV: 肱-踝脉搏波传导速度; ABI: 肱踝指数。与尿酸正常组比较, * P＜0.05。 
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表 2 影响高尿酸血症的Logistics回归分析
变量 OR 95%CI P BMI 2.264 1.45~3.64 0.002 高血压 1.865 1.26~2.76 0.002 TG 1.652 0.34~0.86 0.034 FBG 0.426 1.02~2.06 0.006 baPWV 1.264 2.03~3.48 0.002 ABI 2.031 1.03~2.06 0.008 BMI: 体质量指数; TG: 甘油三酯; FBG: 空腹血糖; baPWV: 肱-踝脉搏波传导速度; ABI: 肱踝指数。
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表 3 不同血糖组一般资料比较(x±s)[n(%)]
指标 正常组(n=30) 调节受损组(n=40) 糖尿病组(n=30) 男 11(36.67) 15(37.50) 20(40.00) 年龄/岁 40.12±5.26 40.34±5.25 40.12±5.64 BMI/(kg/m2) 25.56±3.15 25.13±3.01 27.31±3.01 腰臀比 0.85±0.08 0.97±0.07* 0.93±0.08* 舒张压/mmHg 76.23±10.48 76.29±10.03 76.49±10.03 收缩压/mmHg 130.26±20.16 130.48±20.26 130.29±20.59 脉压(/mmHg 54.26±10.02 55.03±10.59 56.23±10.48 脉率/(次/min) 71.45±10.03 75.49±10.20* 75.49±10.30* HDL-C/(mmol/L) 1.42±0.59 1.37±0.46 1.32±0.48 LDL-C/(mmol/L) 2.01±0.59 2.24±0.49* 2.33±0.48* FBG/(mmol/L) 4.18±0.65 5.40±0.32* 8.56±2.16* 餐后2 h血糖/(mmol/L) 5.79±1.26 6.75±0.59* 12.03±2.48* BMI: 体质量指数; LDL-C: 低密度脂蛋白胆固醇; HDL-C: 高密度脂蛋白胆固醇; FBG: 空腹血糖。与正常组比较, * P＜0.05。
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表 4 组间不同血糖水平血尿酸水平比较
组别 n 血尿酸/(μmol/L) 正常组 30 306.85±67.56 调节受损组 40 343.98±78.43* 糖尿病组 30 409.87±70.86*# 与正常组比较, * P＜0.05; 与调节受损组比较, #P＜0.05。
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