Objective  To investigate the changes and correlations of serum adropin, platelet activating factor (PAF) and glial fibrillary acidic protein (GFAP) in patients with coronary heart disease (CHD) and depression.

  Methods  A total of 163 patients with CHD were selected as objects, the patients were divided into depression group (98 cases including 47 cases of mild depression, 31 cases of moderate depression and 20 cases of moderate depression, HAMD scored ≥ 18) and non-depression group (65 cases, HAMD scored < 18) according to Hamilton Depression Scale (HAMD) score. The levels of serum adropin, PAF and GFAP were detected by enzyme-linked immunosorbent assay (ELISA). Pearson method was used to analyze the correlations between serum adropin and PAF, GFAP levels in CHD patients with depression. Logistic regression analysis was used to analyze the influencing factors of depression in CHD patients.

  Results  The levels of fasting blood glucose, PAF and GFAP in the depression group were higher than those in non-depression group, while the level of serum adropin was lower than that in the non-depressive group (P < 0.05). In the depression group, serum adropin levels in mild, moderate and severe depression patients gradually decreased, while PAF and GFAP levels gradually increased (P < 0.05). Pearson correlation analysis showed that serum adropin level was negatively correlated with PAF and GFAP levels in CHD patients with depression (r=-0.665, -0.643, P < 0.001); multivariate Logistic regression analysis showed that serum adropin level < 49.36 pg/mL, PAF level ≥ 124.47 pg/mL, GFAP level ≥ 12.79 ng/mL were the independent influencing factors of depression in CHD patients (P < 0.05).

  Conclusion  With the aggravation of depression in patients with CHD, serum adropin level is decreased and levels of PAF and GFAP are increased. Serum adropin level is negatively correlated with PAF and GFAP levels, and all of them are independent influencing factors of depression in CHD patients.