Objective  To investigate the correlation of neoadjuvant complications and constitutive features of traditional Chinese medicine(TCM) in patients with osteosarcoma.

  Methods  A total of 74 patients who underwent neoadjuvant therapy for osteosarcoma were recruited. All patients received neoadjuvant therapy before surgery. The occurrence of complications was observed, and the correlation between complications and constitutive features of TCM was analyzed.

  Results  Yang deficiency and qi stagnation constitution were the main TCM constitution types of osteosarcoma patients, followed by phlegm dampness, qi deficiency, dampness heat, and blood stasis as well as yin deficiency constitutions. Gastrointestinal reaction was the most common complication, which related to qi stagnation, yang deficiency, blood stasis, phlegm-dampness and damp-heat constitutions (P < 0.05); TCM constitutions including dampness heat, qi deficiency and qi stagnation types related to liver function damage (P < 0.05); the mucosa damage, nephrotoxicity and cardiotoxicity were relatively rare, among which nephrotoxicity related to qi deficiency, yang deficiency and blood stasis constitutions (P < 0.05); there was no relation between TCM constitution and cardiotoxicity as well as mucosal damage (P>0.05).

  Conclusion  The occurrence of complications during neoadjuvant therapy is closely related to TCM constitution. Therefore, providing intervention from the perspective of TCM constitution for osteosarcoma patients could reduce the incidence of complications.