Objective  To investigate the effect of direct percutaneous transluminal coronary angioplasty (PTCA) combined with stent implantation on N-terminal pro-B type natriuretic peptide (NT-proBNP) and QT dispersion (QTd) in patients with acute myocardial infarction (AMI).

  Methods  A total of 100 AMI patients were divided into observation group (treated by direct PTCA and stent implantation) and control group (treated by recombinant human tissue plasminogen activator) according to stratified sampling method, with 50 cases in each group. NT-proBNP, QTd, 1-year incidence of angina pectoris, recurrent myocardial infarction rate, mortality, left ventricular end diastolic diameter (LVEDd), left ventricular ejection fraction (LVEF), left ventricular end systolic diameter (LVESd) and incidence of complications were compared between the two groups.

  Results  After treatment, NT-proBNP and QTd in the observation group were significantly lower than those in the control group (P < 0.05). The 1-year incidence of angina pectoris and recurrent myocardial infarction rate in the observation group were significantly lower than those in the control group (P < 0.05). After treatment, LVEDd and LVESd in the observation group were significantly lower than those in the control group, while LVEF was significantly higher than that in the control group (P < 0.05). The total incidence of complications in the observation group was 4.00%, which was significantly lower than 18.00% in the control group (P < 0.05).

  Conclusion  Direct PTCA combined with stent implantation shows a significant effect in the treatment of patients with AMI, which can reduce the NT-proBNP, QTd and incidence of complications.