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脑状态指数与脑瘫调整手术患儿呼气末七氟醚浓度的相关性研究

Correlation between cerebral state index and end-tidal concentration of sevoflurane in children with cerebral palsy undergoing adjustment surgery

    摘要
  • 摘要:
      目的  探讨脑状态指数(CSI)与呼气末七氟醚浓度(CETSev)在脑瘫患儿七氟醚全身麻醉期间的相关性。
      方法  选择80例择期下肢调整手术的脑瘫患儿，采用七氟醚全身麻醉和常规监测，持续监测CETSev和CSI。于诱导前(T0)、喉罩置入后(T1)和CETSev 0.8%(T2)、CETSev 1.2%(T3)、CETSev 1.6%(T4)、CETSev 2.0%(T5)、CETSev 2.4%(T6)、CETSev 2.8%(T7)时，以及停吸七氟醚(T8)和下降期CETSev 1.4%(T9)、CETSev 1.2%(T10)、CETSev 1.0%(T11)、CETSev 0.8%(T12)、CETSev 0.6%(T13)、CETSev 0.4%(T14)和喉罩拔除前(T15)、喉罩拔除后(T16)时，记录CETSev和CSI值。分析CETSev和CSI的相关性。
      结果  在CETSev上升期(T0~T7)，T2~T7的CSI低于T0，差异有统计学意义(P < 0.05)；CSI与CETSev呈负相关(r=-0.890，P < 0.001)。在CETSev下降期(T8~T16)，T9~T16的CSI高于T8，差异有统计学意义(P < 0.05)；CSI与CETSev呈负相关(r=-0.889，P < 0.001)。
      结论  在脑瘫调整手术患儿CETSev的上升期和下降期，CSI与CETSev均呈显著负相关，故可通过CSI指导全身麻醉期间的七氟醚精准用药。

     

    Abstract:
      Objective  To investigate the correlation between cerebral state index (CSI) and end-tidal concentration of sevoflurane (CETSev) in children with cerebral palsy during sevoflurane general anesthesia.
      Methods  Eighty children with cerebral palsy for selective lower limb adjustment surgery were selected. Sevoflurane general anesthesia and routine monitoring were performed, and CETSev as well as CSI were continuously monitored. Before induction (T0), after laryngeal mask implantation (T1), CETSev 0.8% (T2), CETSev 1.2% (T3), CETSev 1.6% (T4), CETSev 2.0%(T5), CETSev 2.4% (T6), CETSev 2.8% (T7), stop taking sevoflurane (T8) and declining stages including CETSev 1.4% (T9), CETSev 1.2%(T10), CETSev 1.0% (T11), CETSev 0.8% (T12), CETSev 0.6% (T13), CETSev 0.4% (T14), before (T15) and after (T16) laryngeal mask removal, the values of CETSev and CSI were recorded. The correlation between CETSev and CSI introduction was analyzed.
      Results  During the rising period of CETSev (T0 to T7), the CSI of T2 to T7 was significantly lower than that of T0 (P < 0.05); CSI was negatively correlated with CETSev (r=-0.890, P < 0.001). During the decreasing period of CETSev (T8 to T16), CSI values of T9 to T16 were significantly higher than that of T8 (P < 0.05); CSI was negatively correlated with CETSev (r=-0.889, P < 0.001).
      Conclusion  There is a significant negative correlation between CSI and CETSev in the rising and descending period of CETSev in children with cerebral palsy undergoing palsy adjustment surgery. Therefore, CSI can be used to guide the accurate use of sevoflurane during general anesthesia.

     

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