Objective To study the relationships of serum endothelin 1 (ET-1), nitric oxide (NO) and C-reactive protein (CRP) levels with restenosis in patients with lower extremity arteriosclerosis obliterans (ASO) after stent implantation.

Methods A retrospective analysis was performed on the clinical data of 173 patients with ASO treated with stent implantation. The patients were divided into restenosis group (n=22) and non-stenosis group (n=151) according to the presence or absence of restenosis at one month after operation. The clinical data of the two groups were compared, and the risk factors were analyzed. Receiver operating characteristic (ROC) curve was used to analyze the value of serum ET-1, NO and CRP levels in the diagnosis of restenosis in patients with ASO after stent implantation.

Results The proportion of patients with smoking history, levels of glycated hemoglobin (HbA1c), ET-1, NO and CRP in the restenosis group were higher than those in the non-stenosis group (P < 0.05). Logistic multivariate regression analysis showed that smoking and HbA1c≥6%, ET-1≥60 g/L, NO≥32 μmol/L and CRP≥20 mg/L were independent risk factors for restenosis after STENT implantation in ASO patients (P < 0.05). ROC curve showed that the area under the curve of combined diagnosis of serum ET-1, NO and CRP levels for restenosis in patients with ASO after stent implantation was higher than that of single detection (P < 0.05).

Conclusion Serum ET-1, NO and CRP levels are higher in ASO patients with restenosis after stent implantation, which indicates that these indicators may be involved in the occurrence and development of restenosis.