Objective  To investigate the correlations between levels of serum cholyglycine (CG), soluble growth stimulating gene 2 (sST2) and the viral load in patients with chronic hepatitis B (CHB).

  Methods  A total of 83 CHB patients with antiviral treatment in authors'hospital from March 2019 to March 2020 were selected, and they were divided into high viral load group (n=32), low viral load group (n=21) and negative group (n=30) according to viral load of hepatitis B virus (HBV)-DNA at visit. Serum CG and sST2 levels were measured and compared in the three groups, and the relationships between levels of serum CG, sST2 and the viral load in patients with CHB were analyzed.

  Results  Levels of total bilirubin (TBIL), direct bilirubin (DBIL), aspartate aminotransferase (AST), glutamate aminotransferase (ALT), CG and sST2 in the high viral load group were significantly higher than those in the low viral load group and the negative group (P < 0.05). Kendall's tau-b relevant evaluation showed that the expressions of TBIL, DBIL, AST, ALT, CG and sST2 were positively correlated with the viral load in CHB patients (Kendall's tau-b=0.485, 0.476, 0.523, 0.624, 0.665, 0.598, P < 0.001). General linear bivariate Pearson linear correlation analysis showed that there was a positive correlation between the expressions of serum CG and sST2 in patients with CHB (r=0.818, P < 0.001).

  Conclusion  The levels of serum CG and sST2 in patients with CHB are related to the viral load, which may be an important reason to promote the further progress of the disease.