Correlations between levels of serum cholyglycine, soluble growth stimulating gene 2 and viral load in patients with chronic hepatitis B
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摘要:目的 探讨血清甘胆酸（CG）、可溶性生长刺激表达基因2蛋白（sST2）水平与慢性乙型肝炎（CHB）患者病毒载量的相关性。方法 选择2019年3月—2020年3月在本院接受抗病毒治疗的83例CHB患者，根据就诊时的乙型肝炎病毒（HBV）-DNA病毒载量将患者分为高病毒载量组（n=32）、低病毒载量组（n=21）以及阴性组（n=30）。测定并比较3组血清CG、sST2水平，分析血清CG、sST2水平与CHB患者病毒载量的关系。结果 高病毒载量组总胆红素（TBIL）、直接胆红素（DBIL）、天冬氨酸氨基转移酶（AST）、谷氨酸氨基转移酶（ALT）、CG、sST2水平高于低病毒载量组、阴性组，差异有统计学意义（P < 0.05）。经Kendall's tau-b相关评价结果显示，TBIL、DBIL、AST、ALT、CG、sST2表达与CHB患者病毒载量呈显著正相关（Kendall's tau-b=0.485、0.476、0.523、0.624、0.665、0.598，P均 < 0.001）。一般线性双变量Pearson直线相关性分析检验结果显示，CHB患者血清CG、sST2表达呈显著正相关（r=0.818，P < 0.001）。结论 CHB患者血清CG、sST2水平与病毒载量相关，可能是促进患者病情进一步进展的重要原因。Abstract:Objective To investigate the correlations between levels of serum cholyglycine (CG), soluble growth stimulating gene 2 (sST2) and the viral load in patients with chronic hepatitis B (CHB).Methods A total of 83 CHB patients with antiviral treatment in authors'hospital from March 2019 to March 2020 were selected, and they were divided into high viral load group (n=32), low viral load group (n=21) and negative group (n=30) according to viral load of hepatitis B virus (HBV)-DNA at visit. Serum CG and sST2 levels were measured and compared in the three groups, and the relationships between levels of serum CG, sST2 and the viral load in patients with CHB were analyzed.Results Levels of total bilirubin (TBIL), direct bilirubin (DBIL), aspartate aminotransferase (AST), glutamate aminotransferase (ALT), CG and sST2 in the high viral load group were significantly higher than those in the low viral load group and the negative group (P < 0.05). Kendall's tau-b relevant evaluation showed that the expressions of TBIL, DBIL, AST, ALT, CG and sST2 were positively correlated with the viral load in CHB patients (Kendall's tau-b=0.485, 0.476, 0.523, 0.624, 0.665, 0.598, P < 0.001). General linear bivariate Pearson linear correlation analysis showed that there was a positive correlation between the expressions of serum CG and sST2 in patients with CHB (r=0.818, P < 0.001).Conclusion The levels of serum CG and sST2 in patients with CHB are related to the viral load, which may be an important reason to promote the further progress of the disease.
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表 1 3组患者基线资料比较(x±s)[n(%)]
基线资料 高病毒载量组(n=32) 低病毒载量组(n=21) 阴性组(n=30) 性别 男 18(56.25) 12(57.14) 16(53.33) 女 14(43.75) 9(42.86) 14(46.67) 年龄/岁 40.72±3.25 40.15±3.66 40.38±2.74 体质量指数/(kg/m2) 21.89±0.47 22.12±0.51 21.95±0.43 病程/年 5.08±0.84 5.11±0.63 4.98±0.72 TBIL/(μmol/L) 23.88±1.72 22.11±1.40* 21.19±1.97* DBIL/(μmol/L) 7.96±1.37 7.08±0.81* 6.79±0.67* AST/(U/L) 163.87±11.12 151.90±7.40* 147.16±5.78* ALT/(U/L) 246.64±12.59 217.55±11.50* 211.95±9.66* CG/(mg/L) 34.53±1.79 29.02±1.96* 27.97±2.18* sST2/(ng/mL) 25.88±1.28 18.73±1.19* 19.04±2.47* TBIL: 总胆红素; DBIL: 直接胆红素; AST: 天冬氨酸氨基转移酶; ALT: 谷氨酸氨基转移酶; CG: 甘胆酸; sST2: 可溶性生长刺激表达基因2蛋白。与高病毒载量组比较, *P < 0.05。 
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