Abstract: Insulin resistance (IR) is one of the important factors affecting cardiovascular diseases and various metabolic diseases. It is very important to identify IR before the disease occurs. Triglyceride glucose-body mass (TyG-BMI) index is a new economic and effective index for evaluating IR. In recent years, the role of TyG-BMI in the evaluation of atherosclerosis, prehypertension, prediabetes, hyperuricemia, non-alcoholic fatty liver disease and other common clinical diseases has been confirmed to some extent, and it has become a new research direction. However, there are still few studies on TyG-BMI at home and abroad, and the specific mechanism remains unclear and needs further exploration. This paper reviewed the research progress of TyG-BMI and its relationship with common diseases, in order to provide positive guidance for the early prevention.