Objective  To explore the clinical efficacy and safety of endoscopic ligation combined with foam sclerosing agent injection in treatment of patients with Ⅱ to Ⅲ internal hemorrhoids.

  Methods  A total of 56 patients with Ⅱ to Ⅲ internal hemorrhoids were randomly divided into control group and observation group, with 28 cases in each group. The control group was treated with endoscopic ligation alone, and the observation group was treated with endoscopic ligation combined with lauromacrogol foam sclerosing agent injection. Surgery condition (intraoperative bleeding amount, operation time), total effective rate, postoperative recovery condition (wound healing time, hospitalization time, postoperative pain score, wound bleeding score and anal edema score), incidence of postoperative complication and recurrence rate were compared between two groups.

  Results  There were no significant differences in intraoperative bleeding volume and operation time between the two groups (P>0.05). Total effective rate was 96.43% in the observation group, which showed no significant difference when compared to 89.29% in the control group (P>0.05). In the observation group, the wound healing time and hospitalization time were significantly shorter than the control group, and the pain score, wound bleeding score and anal edema score at 1 week after surgery were also significantly lower than the control group (P < 0.05). The incidence of complications such as postoperative urinary retention, anal infiltration, anal swelling and pain was significantly lower than that in the control group (P < 0.05). The recurrence rate of hemorrhoids within a year in the observation group was significantly lower than that in the control group (P < 0.05).

  Conclusion  Endoscopic ligation combined with foam sclerosing agent injection is effective in the treatment of patients with Ⅱ to Ⅲ internal hemorrhoids, which can quickly improve symptoms and has the advantages of less complications, rapid postoperative recovery, low recurrence rate and good safety.