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海南省海口地区生殖道支原体感染及耐药分析

Analysis of Mycoplasma genitalium infection and drug resistance in Haikou area of Hainan Province

    摘要
  • 摘要:
      目的  分析海口地区生殖道支原体感染及耐药情况。
      方法  采用商品化试剂盒对就诊的10 109例疑似生殖道感染患者的分泌物进行解脲脲原体(Uu)、人型支原体(Mh)检测及药敏试验，并对结果进行统计分析。
      结果  3 491例(34.53%)患者生殖道标本中检出支原体，女性阳性率(37.25%)高于男性(12.94%), 阳性患者年龄段主要集中于21~40岁。Uu感染阳性率为32.04%, Mh感染阳性率为0.41%, Uu合并Mh感染阳性率为2.09%。药敏试验结果显示，支原体对环丙沙星和14、15元环大环内酯类抗菌药耐药率≥90.24%, 对交沙霉素、强力霉素、美满霉素耐药率均≤11.37%。
      结论  海口地区生殖道支原体感染以单纯Uu为主，且女性感染率高于男性，临床治疗可将交沙霉素、强力霉素、美满霉素作为首选药物。

     

    Abstract:
      Objective  To analyze conditions of Mycoplasma genitalium infection and drug resistance in HaiKou area.
      Methods  A commercial kit was used to test Ureaplasma urealytium (Uu) and Mycoplasma humanum (Mh) as well as drug sensitivity in the secretions of 10 109 patients with suspected genital tract infections, and the results were statistically analyzed.
      Results  Mycoplasma was detected in the genital tract specimens of 3 491 patients(34.53%), with a higher rate of positivity in females (37.25%) than in males (12.94%). The patients positive for Mycoplasma were mainly in the age group of 21 to 40 years old. The positive rate of Uu infection was 32.04%, was 0.41% for Mh infection, and was 2.09% for Uu combined with Mh infection. The drug sensitivity test results showed that Mycoplasma was resistant to ciprofloxacin and 14 as well as 15 metacyclic macrolide antimicrobials, with the drug resistance rate of 90.24% and above, and the resistance rate to josamycin, doxycycline and minocycline were≤11.37%.
      Conclusion  Mycoplasma genitalium infections in Haikou area are predominantly simple Uu, and the infection rate is much higher in women than in men, and josamycin, doxycycline and minocycline should be selected as priority drugs in clinical treatment.

     

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