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类风湿关节炎合并冠心病患者冠状动脉病变程度与白细胞介素-6、白细胞介素-17水平的相关性

Correlations of severity of coronary artery disease with levels of interleukin-6 and interleukin-17 in rheumatoid arthritis patients complicated with coronary heart disease

    摘要
  • 摘要:
      目的  探讨类风湿关节炎(RA)合并冠心病(CHD)患者冠状动脉病变程度与白细胞介素-6(IL-6)、白细胞介素-17(IL-17)水平的相关性。
      方法  选取RA合并CHD患者30例为RA合并CHD组, 选取单纯CHD患者30例为CHD组，选取单纯RA患者30例作为RA组。采用流式荧光法检测3组患者IL-6、IL-17水平，分析IL-6、IL-17与Gensini评分的关系。
      结果  RA合并CHD组患者冠状动脉Gensini评分为(42.63±27.30)分，高于CHD组患者的(29.17±22.07)分，差异有统计学意义(P < 0.05)。RA合并CHD组患者IL-6、IL-17水平高于RA组、CHD组, RA组患者IL-6、IL-17水平高于CHD组，差异均有统计学意义(P < 0.05)。Pearson相关性分析结果显示, Gensini评分与IL-6、IL-17水平呈正相关(r=0.351、0.545, P=0.006、0.001)。
      结论  在RA病程以及活动性无差异的情况下, RA合并CHD患者外周血IL-6、IL-17水平以及冠状动脉病变程度高于单纯RA以及单纯CHD患者。

     

    Abstract:
      Objective  To investigate the correlations of the severity of coronary artery disease with the levels of interleukin-6 (IL-6) and interleukin-17 (IL-17) in rheumatoid arthritis (RA) patients complicated with coronary heart disease (CHD).
      Methods  A total of 30 RA patients complicated with CHD were selected as RA combined with CHD group, 30 patients with simple CHD were selected as CHD group, and 30 patients with simple RA were selected as RA group. The levels of IL-6 and IL-17 in the three groups were detected by flow cytometry, and the relationships between IL-6, IL-17 and Gensini score were analyzed.
      Results  Gensini score of coronary artery in the RA combined with CHD group was (42.63±27.30) points, which was significantly higher than (29.17±22.07) points in the CHD group (P < 0.05). The levels of IL-6 and IL-17 in the RA combined with CHD group were significantly higher than those in the RA group and the CHD group, and the levels of IL-6 and IL-17 in the RA group were significantly higher than those in the CHD group (P < 0.05). Pearson correlation analysis showed that Gensini score was positively correlated with IL-6 and IL-17 levels (r=0.351, 0.545, P=0.006, 0.001).
      Conclusion  Based on no differences in the course and activity of RA, the levels of IL-6 and IL-17 in peripheral blood and the severity of coronary artery disease in RA patients with CHD are higher and greater than those in single RA patients and single CHD patients.

     

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