Abstract: Interleukin (IL)-1 family cytokines can be expressed in many tissues and cells and participate in the occurrence and development of many diseases through multiple signaling pathways, and their main functions are to regulate the growth, differentiation and activation of immune cells in the inflammatory or immune response as well as participate in many physiological and pathological responses of the body. IL-1 family has 11 members, most of which are proinflammatory cytokines. These cytokines play important roles in immune regulation and inflammatory process by stimulating the expression of genes related to inflammation and autoimmune diseases. In recent years, more and more studies have reported the role of IL-1 family members in preeclampsia. This study reviewed the research progress of IL-1 family cytokines in preeclampsia, in order to provide new ideas for the diagnosis and treatment of preeclampsia.