Role of type 3 innate lymphoid cell in airway immunity in children
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摘要: 肺上皮细胞受到刺激后会分泌炎性介质，激活气道中驻留的免疫细胞以发挥保护作用，其中包括固有淋巴细胞，虽然固有淋巴细胞在肺组织中的数量较少，但能分泌大量细胞因子参与免疫应答。3型固有淋巴细胞（ILC3）是固有淋巴细胞的重要亚型，ILC3及其分泌的细胞因子如白细胞介素（IL）-17、IL-22在呼吸道感染中发挥着清除病原、促进黏膜修复及维持黏膜屏障稳态的免疫防御作用。本文总结了ILC3的发育历程、活化机制，对儿童气道炎性疾病的作用及最新研究进展。Abstract: Epithelial cells of the lungs secrete inflammatory mediators to activate resident immune cells in the airway for immune protection after stimulation, including innate lymphoid cells. Although the number of innate lymphoid cells is less, they can secrete numerous cytokines involving in immune response. Type 3 innate lymphoid cells (ILC3) are important subtype of innate lymphoid cells. ILC3 and its secreted cytokines interleukin (IL)-17 and IL-22 play immune defense roles in clearing pathogens, promoting mucosal repair and maintaining mucosal barrier homeostasis in respiratory infections. In this review, the development and activation mechanisms of ILC3 and its roles in pediatric airway inflammatory diseases, and latest research progress were summarized.
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