Abstract: Heart failure (HF) is a complex clinical syndrome caused by various cardiovascular diseases. At present, the high morbidity and mortality of HF is important health problems that mankind face. Galectin-3(Gal-3) is a novel biomarker discovered in recent years, which is believed to be closely related to cardiac fibrosis, ventricular remodeling and inflammatory response, and may affect the prognosis of HF. This paper reviewed the research progress on the role of Gal-3 in HF.