Abstract: Atherosclerosis (AS) is an important pathological basis of cardiovascular and cerebrovascular diseases such as coronary heart disease and stroke. In addition to risk factors such as lipid metabolism disorder, vascular smooth muscle cell (VSMC) activation and oxidative stress response, inflammatory response mediated by inflammatory signaling pathway is a new risk factor throughout the formation and development of AS, which has been recognized by researchers. This paper reviewed the mechanism of the main inflammatory signaling pathways in AS and the research progress of the relationships of the signaling pathways in order to provide new ideas for the treatment of AS by inhibiting inflammation.