Abstract: Sepsis patients often have gastrointestinal function injury which is getting more and more attention, and has become a problem that cannot be ignored. Gastrointestinal function injury not only has a high incidence, but also has a very important role in the occurrence and development of multiple organ dysfunction syndrome(MODS), which has an role that cannot be ignored in patients′ disease condition and prognosis. There is no specific evaluation indexes for gastrointestinal function injury in patients with sepsis, so some new detection methods need to be further studied. Therefore, it is very important to explore effective detection indexes for the clinical treatment of this disease. This paper reviewed progress of gastrointestinal function injury mechanisms and related serological detection methods in patients with sepsis, aiming to provide a reference for the diagnosis and treatment of gastrointestinal dysfunction in sepsis.