Clinical study of Huoxue Zishen Prescription in treating endometriosis of kidney deficiency and blood stasis syndrome
-
摘要:目的
探讨活血滋肾方治疗肾虚血瘀型子宫内膜异位症的效果。
方法选择肾虚血瘀型子宫内膜异位症患者96例为研究对象, 根据随机数字表法分为2组，对照组48例给予戈舍瑞林进行治疗，研究组48例在此基础上给予活血滋肾方进行治疗。比较2组临床效果、性激素水平、炎症因子水平、不良反应发生率、妊娠情况。
结果研究组总有效率为89.58%, 高于对照组的72.92%, 差异有统计学意义(P < 0.05)。治疗后, 2组血清雌二醇(E2)、黄体生成素(LH)、卵泡刺激素(FSH)水平均低于治疗前，且研究组以上指标水平低于对照组，差异有统计学意义(P < 0.05)。治疗后, 2组白细胞介素-8(IL-8)、可溶性细胞间黏附分子(sICAM-1)、肿瘤坏死因子-α(TNF-α)均低于治疗前，且研究组以上指标水平低于对照组，差异有统计学意义(P < 0.05)。研究组不良反应发生率为6.25%, 低于对照组的20.83%, 差异有统计学意义(P < 0.05)。2组治疗后均随访6个月，研究组临床妊娠成功率为45.83%, 高于对照组的25.00%, 差异有统计学意义(P < 0.05)。
结论活血滋肾方治疗肾虚血瘀型子宫内膜异位症的疗效显著，能明显改善性激素和炎症因子水平，提高妊娠率，且不良反应少。
Abstract:ObjectiveTo explore the effect of Huoxue Zishen Prescription in treating endometriosis of kidney deficiency and blood stasis syndrome.
MethodsA total of 96 patients with endometriosis of kidney deficiency and blood stasis syndrome were selected as study subjects, and were divided into two groups according to random number table method. A total of 48 patients in the control group were treated with goserelin, and 48 patients in the study group were treated with Huoxue Zishen Prescription on basis of the control group. The clinical effect, sex hormone level, inflammatory factor level, adverse reaction rate and pregnancy were compared.
ResultsThe total effective rate of the study group was 89.58%, which was higher than 72.92% of the control group (P < 0.05). The serum estradiol (E2), luteinizing hormone (LH) and serum follicle stimulating hormone (FSH) in the two groups after treatment were lower than those before treatment (P < 0.05), and the above indicators in the study group were lower than those in the control group (P < 0.05). After treatment, the levels of interleukin (IL-8), soluble intercellular adhesion molecule (sICAM-1), tumor necrosis factor-α (TNF-α) in the two groups were lower than those before treatment, and were lower in the study group than those in the control group (P < 0.05). The incidence of adverse reactions in the study group was 6.25%, which was lower than 20.83% in the control group (P < 0.05). Both groups were followed up for 6 months after treatment, the clinical pregnancy success rate of the study group was higher than that of the control group (45.83% versus 25.00%, P < 0.05).
ConclusionHuoxue Zishen Prescription has a significant therapeutic effect in treating endometriosis of kidney deficiency and blood stasis syndrome. It can obviously improve the levels of sex hormone and inflammatory factors, increase pregnancy rate, and have fewer adverse reactions.
-
-
表 1 2组临床效果比较[n(%)]
组别 n 痊愈 显效 有效 无效 总有效 对照组 48 5(10.42) 19(39.58) 11(22.92) 13(27.08) 35(72.92) 研究组 48 11(22.92) 20(41.67) 12(25.00) 5(10.42) 43(89.58)* 与对照组比较, * P < 0.05。 
下载: 导出CSV
表 2 2组性激素水平比较(x±s)
组别 时点 雌二醇/(μmol/L) 黄体生成素/(U/L) 卵泡刺激素/(U/L) 对照组(n=48) 治疗前 160.29±31.53 7.16±1.72 8.34±1.76 治疗后 93.12±19.55* 6.22±1.58* 6.37±1.42* 研究组(n=48) 治疗前 158.22±30.48 7.23±1.68 8.38±1.79 治疗后 63.28±15.42*# 5.38±1.43*# 4.23±1.05*# 与治疗前比较, * P < 0.05; 与对照组比较, #P < 0.05。
下载: 导出CSV
表 3 2组炎症因子水平比较(x±s)
组别 时点 白细胞介素-8/(ng/mL) 可溶性细胞间黏附分子/(pg/mL) 肿瘤坏死因子-α/(ng/mL) 对照组(n=48) 治疗前 48.07±11.13 4 353.59±170.83 30.16±5.05 治疗后 32.63±9.42* 4 085.84±126.96* 18.63±3.29* 研究组(n=48) 治疗前 48.14±11.16 4 354.17±171.06 30.11±5.01 治疗后 26.42±7.59*# 3 623.48±96.42*# 14.84±2.95*# 与治疗前比较, * P < 0.05; 与对照组比较, #P < 0.05。
下载: 导出CSV
-
[1] 张利平, 李娜. 雌激素阈值理论指导下的子宫内膜异位症术后巩固治疗研究[J]. 实用临床医药杂志, 2019, 23(5): 93-95, 99. doi: 10.7619/jcmp.201905026 [2] 张春晓. 子宫内膜异位症相关性不孕患者腹腔镜术后妊娠情况及影响因素分析[J]. 中国妇幼保健, 2018, 33(12): 2761-2764. https://www.cnki.com.cn/Article/CJFDTOTAL-ZFYB201812043.htm [3] 孙宏平, 肖惠超. 腹腔镜手术治疗绝经期卵巢子宫内膜异位囊肿的有效性与安全性[J]. 实用临床医药杂志, 2019, 23(5): 83-85. doi: 10.7619/jcmp.201905023 [4] 李潇, 周艳艳. 补肾活血方对肾虚血瘀型子宫内膜异位症不孕患者子宫内膜容受性的影响[J]. 陕西中医, 2018, 39(3): 341-344. doi: 10.3969/j.issn.1000-7369.2018.03.022 [5] 中华医学会妇产科学分会子宫内膜异位症协作组. 子宫内膜异位症的诊治指南[J]. 中华妇产科杂志, 2015, 50(3): 161-169. https://xuewen.cnki.net/CCND-JIKA202201140050.html [6] 郑筱萸. 中药新药临床研究指导原则: 试行[M]. 北京: 中国医药科技出版社, 2002: 58-58. [7] 张玉珍. 中医妇科学[M]. 北京: 中国中医药出版社, 2002: 141-146. [8] 方立秀, 张小花, 刘双萍. 温胞饮加减联合穴位埋线治疗子宫内膜异位症痛经肾虚血瘀证30例临床观察[J]. 甘肃中医药大学学报, 2018, 35(1): 84-87. https://www.cnki.com.cn/Article/CJFDTOTAL-GSZX201801026.htm [9] 赵倩倩, 倪喆鑫, 毕艳丽, 等. 化瘀解毒方改善子宫内膜异位症小鼠肠道菌群及粪便代谢组[J]. 中国实验方剂学杂志, 2021, 27(9): 202-214. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSFX202109030.htm [10] 秦翠梅, 于洪建, 陈建梅, 等. 三棱-莪术有效组分配伍液对慢性盆腔炎大鼠盆腔粘连的影响[J]. 中成药, 2018, 40(6): 1233-1237. https://www.cnki.com.cn/Article/CJFDTOTAL-ZCYA201806001.htm [11] 程杰, 曹秀莲, 曹文利, 等. 三棱莪术配方颗粒配伍对子宫内膜异位模型大鼠的改善作用及机制初探[J]. 中药药理与临床, 2018, 34(4): 134-138. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYYL201804034.htm [12] 杨秀娟, 邓毅, 杨志军, 等. 当归不同药用部位对急性血瘀模型大鼠的活血作用[J]. 中国临床药理学杂志, 2018, 34(18): 2187-2190. https://www.cnki.com.cn/Article/CJFDTOTAL-GLYZ201818016.htm [13] KRASNYI A M, SADEKOVA A A, SEFIHANOV T G, et al. The content of cytokines IL-6, IL-8, TNF-α, IL-4 and the level of expression in macrophages CD86 and CD163 in peritoneal fluid has a reverse correlation with the degree of severity of external genital endometriosis[J]. Biomeditsinskaia Khimiia, 2019, 65(5): 432-436.
[14] PROESTLING K, YOTOVA I, GAMPERL S, et al. Enhanced expression of TACE contributes to elevated levels of sVCAM-1 in endometriosis[J]. Mol Hum Reprod, 2018, 25(2): 76-87.
[15] BABAABASI B, AHANI A, SADEGHI F, et al. The association between TNF-alpha gene polymorphisms and endometriosis in an Iranian population[J]. Int J Fertil Steril, 2019, 13(1): 6-11.
-
期刊类型引用(6)
1. 黄晨岚. 25羟维生素D、超敏c反应蛋白、估计肾小球滤过率与脑萎缩相关性的临床研究. 黑龙江医药. 2024(01): 44-47 . 
百度学术
2. 桂千，侯晓夏，徐勤荣，冯红选，吴冠会，卢艳丽，程庆璋. 脑微出血与非关键部位脑梗死患者认知功能的相关性. 实用临床医药杂志. 2023(13): 43-47+52 . 本站查看
3. 蹇秋枫，徐荣华，姚倩，周媛媛. 中国老年脑卒中患者认知障碍患病率和影响因素的Meta分析. 中国全科医学. 2023(32): 4070-4079+4088 . 百度学术
4. 李梦洁，肖佳男，刘文娟，练芮含，张丽秀. 外周血1, 25-(OH)_2D_3、神经元特异性烯醇化酶、神经胶质纤维酸性蛋白在小儿复杂性惊厥中的表达意义. 中国儿童保健杂志. 2023(11): 1254-1259 . 百度学术
5. 张丽. 脑梗死后认知功能损害与神经功能恢复及生活质量的相关性研究. 临床研究. 2022(08): 77-80 . 百度学术
6. 雷霄明，薛孟周，夏彬，李晶，郭平平. 血清25-羟维生素D和脂联素与脑白质损伤患者认知功能的相关性研究. 实用临床医药杂志. 2022(19): 33-37 . 本站查看
其他类型引用(1)
计量
- 文章访问数:
- HTML全文浏览量:
- PDF下载量:
- 被引次数: 7
苏公网安备 32100302010246号