Objective  To investigate the application and clinical significance of using membrane as anatomical marker in laparoscopic totally extraperitoneal inguinal hernioplasty (TEP).

Methods  A total of 100 patients with inguinal hernia were selected and divided into observation group (n=50) and control group(n=50). The control group performed TEP, while the observation group performed TEP taking membrane as anatomic mark. Operation time, drainage tube placement time, hospital stay, establishment time of operation space and stress hormone were compared between the two groups.

Results  There were significant differences in intraoperative blood loss, operation space establishment time, drainage tube placement time, total volume of drainage fluid, postoperative pain score and hospital stay between the two groups (P < 0.05). Before operation, there were no significant differences in levels of cortisol (Cor), norepinephrine (NE) and aldosterone (ALD) in two groups (P>0.05). After operation, the levels of Cor, NE and ALD in the observation group were (261.23±12.35) nmol/L, (96.56±13.32) μg/L and (13.26±2.84) ng/dL, respectively, which were lower than (415.12±14.41) nmol/L, (108.36±15.63) μg/L and (20.26±3.10) ng/dL in the control group, and the differences were statistically significant (P < 0.05).

Conclusion  Laparoscopic TEP using membrane as anatomic landmark can safely, quickly and effectively establish the surgical operation space, accelerate the recovery, and relieve the traumatic stress response of patients. Laparoscopic TEP under the guidance of precision concept is safe and reliable, and is worthy of clinical promotion.