组织工程领域中过氧化物的研究进展

Research progress of peroxide in field of tissue engineering

  • 摘要: 在植入物与宿主整合的过程中, 如何维持细胞活力和代谢活性对于工程组织的存活和功能至关重要。过氧化物可被用作氧释放材料来减少细胞凋亡,提高工程组织存活率和成功率。过氧化物通过氧气释放对细菌产生抑制作用,释放主要机制是水解,常用的过氧化物包括过氧化钠、过氧化钙、过氧化钠和过氧化氢等。本文综述了不同类型过氧化物在骨、胰腺、心血管、皮肤、抗菌等组织方面的研究进展。

     

    Abstract: During the integration of implants and hosts, how to maintain cell viability and metabolic activity is very important for the survival and function of engineered tissue. Peroxides can be used as oxygen releasing materials to reduce apoptosis and increase the survival and success rate of engineered tissues. Peroxides can inhibit bacteria through the release of oxygen, the main mechanism of release is hydrolysis, and commonly used peroxides include sodium peroxide, calcium peroxide, sodium peroxide and hydrogen peroxide. This paper reviewed the research progress of different types of peroxides in bone, pancreas, cardiovascular, skin, antibacterial and other tissues.

     

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