Abstract: Nautical motion sickness is a common nautical disease and an important subtype of motion sickness. With the development of civil navigation and navy national defense, navigation activities are constantly moving from offshore to outer ocean area, and the increasingly frequent long-distance navigation tasks lead to more frequently occurrence of motion sickness, which seriously affects the working efficiency of seafarers. With the deepening understanding of CINV, the incidence of CINV has been effectively controlled through prevention and control mechanisms such as accurate prediction, precise medication and joint strategies. From the perspective of precise prevention and control for CINV, this study analyzed the strategies of precise prediction and comprehensive prevention and control for nautical motion sickness, so as to enable seafarers to better adapt to long-distance missions, and also provide a new direction for the study of nautical motion sickness.