Research progress in non-coding RNA in radon-induced lung cancer
-
摘要:
肺癌的发病率和病死率位居全球癌症的前列，氡及其子体是仅次于吸烟的第2大危险因素。非编码RNA是生物过程中重要的调控因子，并通过表观遗传、转录以及转录后调控细胞的发育、增殖分化和凋亡影响肿瘤的发生和发展。然而，非编码RNA在氡诱导的肺癌中的作用机制尚不明确。本文综述了氡致肺癌组织中异常表达的非编码RNA, 并阐述其在氡致肺癌中的作用机制，以期为氡致肺癌的防治提供新的思路。
Abstract:The incidence and mortality of lung cancer are in the forefront of all cancers in the world. Radon and its daughters are the second biggest risk factors after smoking. Non-coding RNA is an essential regulator of biological processes and affects tumor development through epigenetic, transcriptional, and post-transcriptional regulation of cell development, proliferation differentiation, and apoptosis. However, the mechanism of the role of non-coding RNA in radon-induced lung cancer is unclear. This paper mainly reviewed the non-coding RNAs aberrantly expressed in tissues of radon-induced lung cancer and elaborated on its mechanism in radon-induced lung cancer so as to provide new ideas for prevention and clinical treatment of radon-induced lung cancer.
-
Keywords:
- radon /
- lung cancer /
- non-coding RNA /
- microRNA /
- long non-coding RNA
-
-
[1] LORENZO-GONZÁLEZ M, TORRES-DURÁN M, BARBOSA-LORENZO R, et al. Radon exposure: a major cause of lung cancer[J]. Expert Rev Respir Med, 2019, 13(9): 839-850. doi: 10.1080/17476348.2019.1645599
[2] GRZYWA-CELINSKA A, KRUSINSKI A, MAZUR J, et al. Radon—the element of risk. the impact of radon exposure on human health[J]. Toxics, 2020, 8(4): 120. doi: 10.3390/toxics8040120
[3] SUNG H, FERLAY J, SIEGEL R L, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries[J]. CA Cancer J Clin, 2021, 71(3): 209-249. doi: 10.3322/caac.21660
[4] RAGE E, RICHARDSON D B, DEMERS P A, et al. PUMA-pooled uranium miners analysis: cohort profile[J]. Occup Environ Med, 2020, 77(3): 194-200. doi: 10.1136/oemed-2019-105981
[5] RAGE E, CAËR-LORHO S, LAURIER D. Low radon exposure and mortality among Jouac uranium miners: an update of the French cohort (1946-2007)[J]. J Radiol Prot, 2018, 38(1): 92-108. doi: 10.1088/1361-6498/aa8d97
[6] KELLY-REIF K, SANDLER D P, SHORE D, et al. Lung and extrathoracic cancer incidence among underground uranium miners exposed to radon progeny in the Príbram region of the Czech Republic: a case-cohort study[J]. Occup Environ Med, 2022, 79(2): 102-108. doi: 10.1136/oemed-2021-107392
[7] BARBOSA-LORENZO R, BARROS-DIOS J M, RAÍCES ALDREY M, et al. Residential radon and cancers other than lung cancer: a cohort study in Galicia, a Spanish radon-prone area[J]. Eur J Epidemiol, 2016, 31(4): 437-441. doi: 10.1007/s10654-016-0134-x
[8] HASSFJELL C S, GRIMSRUD T K, STANDRING W, et al. Lung cancer incidence associated with radon exposure in Norwegian homes[J]. Tidsskr Nor Laegeforen, 2017, 137(14/15): 2017Aug21; 137(14-2017Aug21; 137(15).
[9] 陶立静. miR-590-3p和TFAM在氡致肺损伤中的表达改变及靶向调控作用[D]. 苏州: 苏州大学, 2017. [10] CHAUDHURY D, SEN U, BHAT N N, et al. Lung damage by Thoron progenies versus possible damage redemption by lung stem cells: a perspective[J]. Int J Radiat Biol, 2020, 96(11): 1362-1373. doi: 10.1080/09553002.2020.1820597
[11] WU Q Q, FANG L J, YANG Y J, et al. Protection of melatonin against long-term radon exposure-caused lung injury[J]. Environ Toxicol, 2021, 36(4): 472-483. doi: 10.1002/tox.23052
[12] CHEN H Q, CHEN N, LI F S, et al. Repeated radon exposure induced lung injury and epithelial-mesenchymal transition through the PI3K/AKT/mTOR pathway in human bronchial epithelial cells and mice[J]. Toxicol Lett, 2020, 334: 4-13. doi: 10.1016/j.toxlet.2020.09.008
[13] XU Q, FANG L J, CHEN B, et al. Radon induced mitochondrial dysfunction in human bronchial epithelial cells and epithelial-mesenchymal transition with long-term exposure[J]. Toxicol Res (Camb), 2018, 8(1): 90-100.
[14] 裴炜炜, 陶立静, 聂继华, 等. 氡暴露致小鼠肺组织线粒体转录因子A及核因子-κB表达的改变[J]. 环境与职业医学, 2016, 33(4): 385-389. https://www.cnki.com.cn/Article/CJFDTOTAL-LDYX201604020.htm [15] 陈玉之, 李冰燕, 孙静, 等. 线粒体部分敲除对氡染毒人支气管上皮细胞损伤效应的影响[J]. 环境与职业医学, 2014, 31(6): 438-441. https://www.cnki.com.cn/Article/CJFDTOTAL-LDYX201406005.htm [16] DE VOCHT F, SUDERMAN M, RUANO-RAVINA A, et al. Residential exposure to radon and DNA methylation across the lifecourse: an exploratory study in the ALSPAC birth cohort[J]. Wellcome Open Res, 2019, 4: 3. doi: 10.12688/wellcomeopenres.14991.2
[17] HUANG H H, JI Y H, ZHANG J Y, et al. Aberrant DNA methylation in radon and/or cigarette smoke-induced malignant transformation in BEAS-2B human lung cell line[J]. J Toxicol Environ Health A, 2017, 80(23/24): 1321-1330.
[18] 纪雅慧, 韦晔, 刘玉萍, 等. DNMTs在长期氡暴露致BEAS-2B细胞恶性转化过程中的作用[J]. 毒理学杂志, 2015, 29(2): 90-94. https://www.cnki.com.cn/Article/CJFDTOTAL-WSDL201502003.htm [19] 黄欢欢, 纪雅慧, 苏志刚, 等. DNA异常甲基化在氡与香烟烟雾致BEAS-2B细胞恶性转化过程中的作用[C]. 中国毒理学会第七次全国毒理学大会暨第八届湖北科技论坛论文集. 2015. [20] 韦晔. DNA甲基化在氡致BEAS-2B细胞恶性转化过程中的作用[D]. 苏州: 苏州大学, 2014. [21] ANASTASIADOU E, JACOB L S, SLACK F J. Non-coding RNA networks in cancer[J]. Nat Rev Cancer, 2018, 18(1): 5-18. doi: 10.1038/nrc.2017.99
[22] 马尘超. 非编码RNA在胰腺癌发生、发展中的作用及机制研究[D]. 上海: 上海交通大学, 2016. [23] HASHEMI Z S, KHALILI S, FOROUZANDEH MOGHADAM M, et al. Lung cancer and miRNAs: a possible remedy for anti-metastatic, therapeutic and diagnostic applications[J]. Expert Rev Respir Med, 2017, 11(2): 147-157. doi: 10.1080/17476348.2017.1279403
[24] DANG X H, LIN H P, LI Y C, et al. microRNA profiling in BEAS-2B cells exposed to alpha radiation reveals potential biomarkers for malignant cellular transformation[J]. Toxicol Res (Camb), 2020, 9(6): 834-844.
[25] CUI F M, LI J X, CHEN Q, et al. Radon-induced alterations in micro-RNA expression profiles in transformed BEAS2B cells[J]. J Toxicol Environ Health A, 2013, 76(2): 107-119. doi: 10.1080/15287394.2013.738176
[26] SUN L, PAN Y, WANG X C, et al. Screening for potential biomarkers in peripheral blood from miners exposed to radon radiation[J]. Dose Response, 2020, 18(1): 1559325820904600.
[27] 赵倩, 李宝生. let-7在肺癌中的研究进展[J]. 中华肿瘤防治杂志, 2015, 22(7): 564-568. https://www.cnki.com.cn/Article/CJFDTOTAL-QLZL201507021.htm [28] CHEN Z H, WANG D P, GU C, et al. Down-regulation of let-7 microRNA increased K-ras expression in lung damage induced by radon[J]. Environ Toxicol Pharmacol, 2015, 40(2): 541-548. doi: 10.1016/j.etap.2015.08.009
[29] WU X, LIU T, FANG O, et al. miR-194 suppresses metastasis of non-small cell lung cancer through regulating expression of BMP1 and p27(kip1)[J]. Oncogene, 2014, 33(12): 1506-1514. doi: 10.1038/onc.2013.108
[30] WU J, SUN B, ZHANG S Y, et al. Effects of radon on miR-34a-induced apoptosis in human bronchial epithelial BEAS-2B cells[J]. J Toxicol Environ Health A, 2019, 82(16): 913-919. doi: 10.1080/15287394.2019.1665350
[31] 高刚, 杨英杰, 刘建香, 等. α粒子诱发人支气管上皮细胞转化不同时期miR-200家族表达的研究[J]. 中国辐射卫生, 2013, 22(2): 135-137. https://www.cnki.com.cn/Article/CJFDTOTAL-REDI201302004.htm [32] 高刚. 氡致肺癌及肺损伤相关microRNAs的研究[D]. 北京: 中国疾病预防控制中心, 2010. [33] 周翔宇, 李德明, 赵永强. 长链非编码RNA前列腺癌相关转录物1在肿瘤进展中的作用[J]. 实用临床医药杂志, 2019, 23(8): 115-118. doi: 10.7619/jcmp.201908032 [34] 郁冬梅, 郭薇, 雷雯, 等. lncRNA在免疫细胞及自身免疫性疾病中的研究进展[J]. 中国药科大学学报, 2017, 48(3): 371-376. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGYD201703019.htm [35] NIE J H, WU J, CHEN Z H, et al. Expression profiles of long non-coding RNA in mouse lung tissue exposed to radon[J]. J Toxicol Environ Health A, 2019, 82(15): 854-861. doi: 10.1080/15287394.2019.1664011
[36] 刘德慧, 严玉兰. 环状RNA在肺癌诊断及预后中的研究进展[J]. 实用临床医药杂志, 2021, 25(13): 124-128. doi: 10.7619/jcmp.20211851 [37] 董辉, 于航, 王永祥. 环状RNA在骨质疏松症中的作用及机制研究进展[J]. 实用临床医药杂志, 2021, 25(4): 111-115. doi: 10.7619/jcmp.20210167 [38] PEI W W, TAO L J, ZHANG L W, et al. Circular RNA profiles in mouse lung tissue induced by radon[J]. Environ Health Prev Med, 2017, 22(1): 36. doi: 10.1186/s12199-017-0627-6
-
期刊类型引用(4)
1. 张余珍，宋杰，莫定雯. 尿酸、胆固醇、血小板计数、钙联合检测诊断重度子痫前期的特异性及敏感性研究. 实用妇科内分泌电子杂志. 2022(10): 14-16 . 
百度学术
2. 黄新新，李晓斌，李海，李璇玥，李倩，马利鑫，陈晖，马玉辉. 不同品种1岁青年马血清生化指标的比较分析. 新疆农业科学. 2021(09): 1740-1746 . 百度学术
3. 朱明慧，陈烨，王婵妮. 钙剂联合低分子肝素钠在子痫前期中的应用研究. 中国妇幼保健. 2020(05): 837-839 . 百度学术
4. 周南玲，周冰，高梅. 小剂量阿司匹林联合钙剂、维生素E治疗妊娠期高血压疾病的疗效评价. 中国计划生育学杂志. 2020(03): 349-352 . 百度学术
其他类型引用(1)
计量
- 文章访问数: 148
- HTML全文浏览量: 96
- PDF下载量: 20
- 被引次数: 5
下载:
苏公网安备 32100302010246号