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硫酸镁与硝苯地平对妊娠期高血压疾病孕妇血流动力学和妊娠结局的影响比较

Comparison of magnesium sulfate and nifedipineon hemodynamics and pregnancy outcomes of pregnant woman with hypertensive disorders complicating pregnancy

    摘要
  • 摘要:
    目的  比较硫酸镁与硝苯地平对妊娠期高血压疾病(HDCP)孕妇血流动力学和妊娠结局的影响。
    方法  选取114例HDCP孕妇作为研究对象，按照随机数字表法分为观察组(给予硝苯地平治疗)与对照组(给予硫酸镁治疗)，每组57例。检测2组孕妇全血高切黏度(HBV)、全血低切黏度(LBV)、血浆黏度(PV)、抗心磷脂抗体免疫球蛋白G(ACA-IgG)和抗心磷脂抗体免疫球蛋白M(ACA-IgM)水平，并观察2组孕妇的不良反应、妊娠结局。
    结果  治疗前, 2组HBV、LBV、PV、ACA-IgG和ACA-IgM水平比较，差异无统计学意义(P>0.05); 治疗后, 2组HBV、LBV、PV、ACA-IgG和ACA-IgM水平均低于治疗前，且观察组HBV、LBV、PV、ACA-IgG和ACA-IgM水平均低于对照组，差异有统计学意义(P < 0.05)。观察组不良反应总发生率为7.02%, 与对照组不良反应总发生率5.26%相比，差异无统计学意义(P>0.05)。观察组早产率、新生儿窒息率、剖宫产率分别为10.53%、3.51%、22.81%, 低于对照组的31.58%、21.05%、43.86%, 差异有统计学意义(P < 0.05)。
    结论  硫酸镁与硝苯地平治疗HDCP均能起到改善血流动力学和妊娠结局的效果，但硝苯地平改善效果更佳。

     

    Abstract:
    Objective  To compare the effects of magnesium sulfate and nifedipine on hemodynamics and pregnancy outcomes of pregnant women with hypertensive disorders complicating pregnancy (HDCP).
    Methods  A total of 114 pregnant women with HDCP were selected as research objects, and were divided into observation group (treated by nifedipine) and control group (treated by magnesium sulfate) according to random number table method, with 57 cases in each group. The levels of whole blood high shear viscosity (HBV), whole blood low shear viscosity (LBV), plasma viscosity (PV), anti-cardiolipin antibody immunoglobulin G (ACA-IgG) and anti-cardiolipin antibody immunoglobulin M (ACA-IgM) in pregnant women in two groups were detected, and their adverse reactions and pregnancy outcomes were observed.
    Results  Before treatment, there were no significant differences in HBV, LBV, PV, ACA-IgG, ACA-IgM between the two groups (P>0.05). After treatment, the levels of HBV, LBV, PV, ACA-IgG and ACA-IgM in two groups were lower than treatment before, and were lower in the observation group than those in the control group (P < 0.05). The total incidence of adverse reactions in the observation group was 7.02%, which showed no statistically significant difference compared with 5.26% in the control group (P>0.05). The premature birth rate, neonatal asphyxia rate and cesarean section rate in the observation group were 10.53%, 3.51% and 22.81%, which were lower than 31.58%, 21.05% and 43.86% in the control group (P < 0.05).
    Conclusion  Both magnesium sulfate and nifedipine in treating HDCP can improve hemodynamics and pregnancy outcomes, but nifedipine has better improvement in efficacy.

     

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