Objective  To analyze the clinical distribution characteristics and drug-resistant condition of Staphylococcus aureus (SA) in the First Affiliated Hospital of Naval Medical University of the Chinese People′s Liberation Army (called our hospital in the following text) from 2016 to 2020, so as to provide a basis for rational clinical application of antibacterial agents.

Methods  SA strains isolated from samples of 1 575 patients in our hospital from January 2016 to December 2020 were retrospectively analyzed. WHONET 5.6 software and SPSS software were used to statistically analyze the department distribution, sample source and drug resistance of the strains.

Results  A total of 1 784 strains were isolated from the samples, including 926 strains (51.9%) of methicillin resistant Staphylococcus aureus (MRSA). The highest detection rate of SA occurred in burn department (15.5%), followed by respiratory department (7.3%) and department of plastic surgery (5.9%). SA strains were mainly derived from respiratory tract samples (44.6%), followed by secretion (30.4%) and blood (5.6%). From year of 2016 to 2020, the resistance rate of SA to penicillin was more than 90%, resistance rates were more than 44.1% to 62.4%to erythromycin and clindamycin, and were more than 29.2% to 44.1%to tetracycline, ciprofloxacin, levofloxacin and moxifloxacin. The overall drug resistance rate of MRSA strains was generally higher than that of SA strains. No SA strains were found to be resistant to tigecycline, linezolid and vancomycin.

Conclusion  The detection rate of SA and MRSA in our hospital is high. Regular monitoring of their clinical distribution and drug resistance has high clinical value for the rational use of antibiotics and the prevention and control of nosocomial infection.