Abstract: Stromal cell derived factor-1 (SDF-1) is a member of CXC chemokine subfamily, and also known as CXC chemokine ligand-12 (CXCL12). SDF-1 is a small protein composed of 89 amino acids, with 2 cysteine residues and 1 amino acid in the middle; its coding sequence is located in 10q11.1, its open code is 270 bp, and it plays a crucial role in cell proliferation, immune regulation, migration, invasion, angiogenesis, immune escape and inflammatory microenvironment. CXCL12 can affect the growth of stem cells, osteoblasts and osteoclasts through different regulatory axes and interactions with different miRNAs, which plays a role in osteoporosis.