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阿伐曲泊帕联合升血饮、硒酵母预防肿瘤化疗所致血小板减少症的随机对照临床研究

A randomized controlled clinical study of avatrombopag combined with Shengxue Decoction and selenium yeast in prevention of thrombocytopenia induced by chemotherapy for tumor

    摘要
  • 摘要:
    目的 观察阿伐曲泊帕联合升血饮、硒酵母预防肿瘤化疗所致血小板减少症的效果。
    方法 将2019年3月-2022年3月霍山县医院收治的80例肿瘤化疗患者根据治疗方法的不同分为对照组和观察组, 每组40例。对照组化疗后采用阿伐曲泊帕联合硒酵母治疗，观察组化疗后采用阿伐曲泊帕联合硒酵母、升血饮治疗。比较2组疗效相关指标。
    结果 观察组血小板计数水平、血小板最低值高于对照组，血小板≤50×109/L的时间、血小板恢复至≥100×109/L的时间短于对照组, 血小板输注率、Ⅲ度以上血小板减少症发生率低于对照组，差异均有统计学意义(P < 0.05)。治疗后, 2组倦怠乏力、纳差食少、少气懒言等症状的中医证候积分均低于治疗前，且观察组上述症状积分均低于对照组，差异有统计学意义(P < 0.05)。观察组化疗相关不良反应发生率为7.50%, 低于对照组的25.00%, 差异有统计学意义(P < 0.05)。治疗后, 2组活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)均短于治疗前，纤维蛋白原(FIB)均高于治疗前，且观察组APTT短于对照组, FIB高于对照组，差异均有统计学意义(P < 0.05)。
    结论 应用阿伐曲泊帕联合升血饮、硒酵母预防治疗肿瘤化疗所致血小板减少症，有助于促进血小板升高，缩短血小板恢复时间，降低血小板减少症发生率，减少化疗相关不良反应。

     

    Abstract:
    Objective To observe the effect of avatrombopag combined with Shengxue Decoction and selenium yeast in preventing thrombocytopenia induced by chemotherapy for tumor.
    Methods According to different therapeutic methods, 80 patients with chemotherapy for tumor in Huoshan County Hospital from March 2019 to March 2022 were divided into control group and observation group, with 40 cases in each group. The control group was treated with avatrombopag and selenium yeast after chemotherapy, while the observation group was treated with avatrombopag, selenium yeast and Shengxue Decoction after chemotherapy. Effect related indicators were compared between two groups.
    Results In the observation group, the platelet count level and the lowest value of platelet were significantly higher than those in the control group, the time of platelet≤50×109/L and time of platelet≥100×109/L were significantly shorter than those in the control group, while the platelet transfusion rate and the incidence of thrombocytopenia above grade Ⅲ were significantly lower than those in control group (P < 0.05). After treatment, the scores of TCM syndrome such as fatigue and lack of strength, poor appetite and less food intake, and lack of qi and no desire to speak in both groups were significantly lower than those before treatment, and the scores of symptoms mentioned above in the observation group were significantly lower than those in the control group (P < 0.05). The incidence of chemotherapy-related adverse reactions in the observation group was 7.50%, which was significantly lower than 25.00% in the control group (P < 0.05). After treatment, the activated partial thromboplastin time (APTT) and prothrombin time (PT) in both groups were significantly shorter than those before treatment, while the fibrinogen (FIB) was significantly higher than that before treatment, and the APTT in the observation group was significantly shorter than that in the control group, while the FIB was significantly higher than that in the control group (P < 0.05).
    Conclusion For the prevention and treatment of patients with thrombocytopenia induced by chemotherapy for tumor, application of avatrombopag combined with Shengxue Decoction and selenium yeast can help promote elevation of platelet, shorten recovery time of platelet, reduce the incidence of thrombocytopenia, and decrease chemotherapy-related adverse reactions.

     

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