Effects of immune-enhancing food and activity program on immunologic function and inflammatory factors in human papillomavirus infected women
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摘要:目的
探讨免疫提高饮食运动方案对人乳头瘤病毒(HPV)感染患者免疫功能及炎症因子水平的影响。
方法选取确诊并接受治疗的184例高危型HPV感染患者作为研究对象，按随机数字表法分为免疫提高组和常规干预组，每组92例。常规干预组实施常规管理方案，开展HPV感染相关知识的健康教育; 免疫提高组在常规干预组基础上实施免疫提高饮食运动方案，即饮食强化管理结合运动指导。观察治疗前后2组患者血清免疫球蛋白指标、炎性因子水平，比较2组患者治疗后自我效能感评分、临床疗效，并分析患者自我效能感评分与临床疗效的相关性。
结果治疗后，2组血清免疫球蛋白指标水平均低于治疗前，且免疫提高组低于常规干预组，差异有统计学意义(P < 0.05); 治疗后, 2组血清白细胞介素(IL)-2水平高于治疗前，且免疫提高组高于常规干预组，差异有统计学意义(P < 0.05); 治疗后, 2组血清IL-4、IL-10水平低于治疗前，且免疫提高组低于常规干预组，差异有统计学意义(P < 0.05)。治疗后，免疫提高组患者自我效能感评分(自我认知、治疗环境、病情控制、自信心评分和总评分)和临床治疗总有效率均高于常规干预组，差异有统计学意义(P < 0.05)。相关性分析结果显示, HPV患者自我效能感评分与临床治疗有效率呈正相关(r=0.652, P < 0.001)。
结论将免疫提高饮食运动方案应用于HPV感染患者，可提升其临床治疗有效率、自我效能感，并改善免疫功能，减轻炎性反应。
Abstract:ObjectiveTo explore the effects of immune-enhancing food and activity program on immunologic function and inflammatory factors in human papillomavirus (HPV) infected women.
MethodsA total of 184 high-risk HPV infection patients who were diagnosed and treated in our hospital were selected. According to the random number table method, they were divided into immunity-enhancing group and routine intervention group, with 92 cases in each group. The routine intervention group adopted the routine management mode to carry out HPV infection-related diseases and knowledge health education program; on the basis of the routine intervention group, the patients in the immune-improving group were given immune-improving therapy(intensive diet management combined with exercise guidance program). The levels of serum immunoglobulin and inflammatory factors related indexes in the two groups were observed before and after treatment, and the self-efficacy score and clinical efficacy of the two groups were compared, and the correlation between the self-efficacy score and clinical efficacy was analyzed.
ResultsAfter treatment, the levels of serum immunoglobulin in the two groups decreased significantly than treatment before, and the indexes levels in the immune-enhancing group decreased more significantly than the routine intervention group (P < 0.05). After treatment, serum interleukin (IL)-2 levels in the two groups were significantly increased, and the level of IL-2 in the immune-enhancing intervention group increased significantly than the routine intervention group (P < 0.05). After treatment, serum IL-4 and IL-10 levels in the two groups were significantly decreased, and were lower in the immunity-enhancing group those in the routine intervention group (P < 0.05). After treatment, self-efficacy including self-cognition, treatment environment, disease control, self-confidence score and total score in the immune-enhancing group were higher than those in routine intervention group (P < 0.05). Spearman correlation coefficient analysis showed that self-efficacy score of HPV infected patients was significantly positively correlated with clinical efficacy (P < 0.05).
ConclusionThe application of immune-enhancing diet and activity program in patients with HPV infection has positive effects in improving clinical effective rate, self-efficacy, immune function and relieving inflammatory response.
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表 1 2组治疗前后血清免疫球蛋白相关指标水平比较(x±s)
g/L 组别 IgG IgM IgA 治疗前 治疗后 治疗前 治疗后 治疗前 治疗后 常规干预组(n=92) 21.02±3.84 17.14±3.05* 1.72±0.34 1.55±0.27* 1.94±0.38 1.74±0.25* 免疫提高组(n=92) 20.46±3.72 12.72±2.37*# 1.74±0.31 1.36±0.23*# 1.92±0.35 1.61±0.22*# IgG: 免疫球蛋白G; IgM: 免疫球蛋白M; IgA: 免疫球蛋白A。与治疗前比较, *P < 0.05; 与常规干预组比较, #P < 0.05。 
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表 2 2组治疗前后血清炎性因子水平比较(x±s)
pg/mL 组别 IL-2 IL-4 IL-10 治疗前 治疗后 治疗前 治疗后 治疗前 治疗后 常规干预组(n=92) 23.11±5.46 33.67±6.09* 31.95±5.62 25.42±5.23* 27.91±5.15 25.21±4.67* 免疫提高组(n=92) 22.92±5.33 45.15±7.12*# 31.13±5.86 20.46±4.57*# 28.18±5.07 22.35±4.43*# IL-2: 白细胞介素-2; IL-4: 白细胞介素-4; IL-10: 白细胞介素-10。与治疗前比较, *P < 0.05; 与常规干预组比较, #P < 0.05。
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表 3 2组患者治疗后自我效能感评分比较(x±s)
分 组别 自我认知评分 治疗环境评分 病情控制评分 自信心评分 总分 常规干预组(n=92) 2.21±0.34 2.08±0.65 1.95±0.47 2.03±0.52 8.27±2.14 免疫提高组(n=92) 3.53±0.46* 3.22±0.49* 3.31±0.58* 3.85±0.73* 13.91±3.25* 与常规干预组比较, *P < 0.05。
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表 4 2组患者临床疗效比较[n(%)]
组别 显效 有效 无效 临床治疗总有效 常规干预组(n=92) 25(27.17) 36(39.13) 31(33.70) 61(66.30) 免疫提高组(n=92) 35(38.05) 45(48.91) 12(13.04) 80(86.96)* 与常规干预组比较, *P < 0.05。
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