伏硫西汀联合正念减压治疗急性创伤后应激性障碍患者的临床效果

王明君; 郑景珍; 李兴; 金亚军; 杨芳

doi:10.7619/jcmp.20223045

伏硫西汀联合正念减压治疗急性创伤后应激性障碍患者的临床效果

1.
开滦总医院普外科, 河北唐山, 063000
2.
唐山市第三医院普外科, 河北唐山, 063000
3.
华北理工大学护理与康复学院, 河北唐山, 063000

详细信息

通讯作者:
杨芳, E-mail: shuixianyf@126.com

中图分类号: R749;R971
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- 文章访问数: 129
- HTML全文浏览量: 58
- PDF下载量: 10
出版历程
- 收稿日期: 2022-09-29
- 修回日期: 2023-01-09
- 网络出版日期: 2023-05-10

Clinical effect of vortioxetine combined with mindfulness decompression in treating acute post-traumatic stress disorder patients

1.
Department of General Surgery, Kailuan General Hospital, Tangshan, Hebei, 063000
2.
Department of General Surgery, Tangshan City Third Hospital, Tangshan, Hebei, 063000
3.
College of Nursing and Rehabilitation, North China University of Science and Technology, Tangshan, Hebei, 063000

摘要

摘要:
目的
观察伏硫西汀联合正念减压治疗急性创伤后应激性障碍患者的临床效果。
方法
选取118例急性创伤后应激性障碍患者，随机分为观察组和对照组，每组59例。观察组以伏硫西汀联合正念减压治疗，对照组以正念减压疗法联合安慰剂治疗。
结果
观察组总有效率为91.53%(54/59), 高于对照组的76.27%(45/59), 差异有统计学意义(P < 0.05)。治疗后，观察组患者的心理弹性量表(CD-RISC)评分包括坚韧性、力量、乐观性及总分均高于对照组，观察组患者钙调蛋白(CaM)、促肾上腺皮质激素(ACTH)、人抗酒石酸酸性磷酸酶(TRAP)水平低于对照组，观察组8-羟化脱氧鸟苷(8-OHdG)、髓过氧化物酶(MPO)水平低于对照组，谷胱甘肽过氧化物酶(GSH-Px)水平高于对照组，差异均有统计学意义(P < 0.05)。观察组、对照组不良反应发生率为13.56%(8/59)、8.47%(5/59), 差异无统计学意义(P>0.05)。
结论
伏硫西汀联合正念减压治疗急性创伤后应激性障碍疗效良好，可改善患者心理弹性，降低炎症反应水平和氧化应激状态。
- 急性创伤后应激性障碍 /
- 正念减压疗法 /
- 伏硫西汀 /
- 心理弹性 /
- 社会支持功能
Abstract:
Objective
To observe the clinical effect of vortioxetine combined with mindfulness decompression in the treatment of patients with acute post-traumatic stress disorder.
Methods
A total of 118 patients with acute post-traumatic stress disorder were selected and randomly divided into observation group and control group, with 59 cases in each group. The observation group was treated with vortioxetine and mindfulness decompression, while the control group was treated with mindfulness decompression and placebo.
Results
The total effective rate of the observation group was 91.53%(54/59), which was significantly higher than 76.27% (45/59) of the control group (P < 0.05). After treatment, the scores of tenacity, strength, optimism and total score of the Connor-Davidson Resilience Scale (CD-RISC) in the observation group were higher than those in the control group; the levels of calmodulin (CaM), adrenocorticotropic hormone (ACTH) and human tartrate resistant acid phosphatase (TRAP) in the observation group were lower than those in the control group; the levels of 8-hydroxydeoxyguanosine (8-OHdG) and myeloperoxidase (MPO) in the observation group were significantly lower than those in the control group, while the level of glutathione peroxidase (GSH-Px) was significantly higher than that in the control group (P < 0.05). The incidence rate of adverse reactions was 13.56% (8/59) in the observation group and 8.47%(5/59) in the control group, and there was no significant difference between two groups (P>0.05).
Conclusion
Vortioxetine combined with mindfulness decompression is effective in the treatment of patients with acute post-traumatic stress disorder, which can improve psychological resilience, and reduce the level of inflammatory reaction and oxidative stress of patients.
- acute post-traumatic stress disorder /
- mindfulness decompression therapy /
- vortioxetine /
- psychological resilience /
- social support function

HTML全文

表 1 2组临床疗效比较[n(%)]

组别	n	显效	有效	无效	总有效
对照组	59	28(47.46)	17(28.81)	14(23.73)	45(76.27)
观察组	59	34(57.63)	20(33.90)	5(8.47)	54(91.53)^*
与对照组比较, *P < 0.05。

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表 2 2组心理弹性评分比较$\left( {\bar x \pm s} \right) $ 分

组别	时点	坚韧性	力量	乐观性	总分
对照组(n=59)	治疗前	22.09±4.98	11.78±3.11	6.28±1.89	40.15±6.09
对照组(n=59)	治疗后	38.17±5.36^*	24.46±4.78^*	9.03±2.56^*	71.66±8.06^*
观察组(n=59)	治疗前	21.12±4.48	11.23±3.02	6.17±1.79	38.52±5.97
观察组(n=59)	治疗后	44.38±5.99^*#	28.20±3.82^*#	11.22±2.89^*#	83.80±9.83^*#
与治疗前比较, *P < 0.05; 与对照组比较, #P < 0.05。

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表 3 2组炎症因子指标水平比较$\left( {\bar x \pm s} \right) $ ng/L

组别	时点	CaM	ACTH	TRAP
对照组(n=59)	治疗前	75.31±8.37	120.75±14.21	31.28±5.11
对照组(n=59)	治疗后	46.81±5.96^*	80.39±11.54^*	18.95±3.97^*
观察组(n=59)	治疗前	76.37±8.92	121.87±14.37	32.18±5.26
观察组(n=59)	治疗后	39.38±5.83^*#	68.27±8.31^*#	14.32±3.39^*#
CaM: 钙调蛋白; ACTH: 促肾上腺皮质激素; TRAP: 人抗酒石酸酸性磷酸酶。与治疗前比较, *P < 0.05; 与对照组比较, #P < 0.05。

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表 4 2组氧化应激指标比较$\left( {\bar x \pm s} \right) $ U/L

组别	时点	8-OHdG	MPO	GSH-Px
对照组(n=59)	治疗前	64.02±7.86	120.89±13.11	56.92±6.33
对照组(n=59)	治疗后	44.88±6.03^*	84.23±8.92^*	84.02±9.16^*
观察组(n=59)	治疗前	65.22±8.74	122.33±14.32	57.38±6.29
观察组(n=59)	治疗后	37.26±5.97^*#	78.80±8.72^*#	93.37±10.29^*#
8-OHdG: 8-羟化脱氧鸟苷; MPO: 髓过氧化物酶; GSH-Px: 谷胱甘肽过氧化物酶。与治疗前比较, *P < 0.05; 与对照组比较, #P < 0.05。

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表 5 2组不良反应发生率比较[n(%)]

组别	n	头晕恶心	呕吐腹泻	面部潮红	盗汗	合计
对照组	59	2(3.39)	1(1.69)	1(1.69)	1(1.69)	5(8.47)
观察组	59	2(3.39)	2(3.39)	2(3.39)	2(3.39)	8(13.56)^*
与对照组比较, *P < 0.05。

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