幽门螺杆菌相关性胃癌与非编码核糖核酸的研究进展

马芷灵; 武云

doi:10.7619/jcmp.20230086

幽门螺杆菌相关性胃癌与非编码核糖核酸的研究进展

马芷灵,
武云^,

内蒙古医科大学包头临床医学院, 内蒙古包头, 014040

详细信息

通讯作者:
武云, E-mail: mzl_7490@163.com

中图分类号: R573;R735.2
计量
- 文章访问数: 176
- HTML全文浏览量: 55
- PDF下载量: 25
出版历程
- 收稿日期: 2023-01-11
- 修回日期: 2023-03-06
- 网络出版日期: 2023-06-06

Research progress of Helicobacter pylori associated gastric cancer and non-coding ribonucleic acid

MA Zhiling,
WU Yun^,

Baotou Clinical Medical College of Inner Mongolia Medical University, Baotou, Inner Mongolia, 014040

摘要

摘要:
幽门螺杆菌感染与胃炎、消化道溃疡、胃癌等消化道疾病的发生发展密切相关。幽门螺杆菌感染导致胃癌发生发展的分子生物学机制复杂，既涉及转录水平的调控，也涉及表观遗传学及转录后水平的调控，其中非编码核糖核酸(RNA)在幽门螺杆菌感染调节癌基因表达以及癌细胞恶性生物学行为中起到重要作用。目前研究较为广泛的非编码RNA包括长链非编码RNA(lncRNA)和微小RNA(miRNA)。本文对胃癌发生发展过程中幽门螺杆菌感染调控lncRNA及miRNA表达的相关临床研究和基础研究进行综述。
- 胃癌 /
- 幽门螺杆菌 /
- 长链非编码RNA /
- 微小RNA
Abstract:
Helicobacter pylori (H.pylori) infection is closely related to the occurrence and development of gastritis, gastrointestinal ulcer, gastric cancer and other gastrointestinal diseases. The molecular biological mechanism of H.pylori infection leading to the occurrence and development of gastric cancer is complex, which involves not only in transcriptional regulation, but also epigenetic and post-transcriptional regulations, and non-coding ribonucleic acid (RNA) plays an important role in H.pylori infection regulating oncogene expression and malignant biological behavior of cancer cells. At present, the widely studied non-coding RNAs include long chain non-coding RNA (lncRNA) and microRNA (miRNA). This paper reviewed the clinical and basic researches related to H.pylori infection regulating the expression of lncRNA and miRNA in the development of gastric cancer.
- gastric cancer /
- Helicobacter pylori /
- long chain non-coding RNA /
- microRNA

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