中性粒细胞与淋巴细胞比值、平均血小板体积与血小板计数比值对感染性休克患者预后的评估价值

郑鹏, 周吉, 吴衡, 陈硕

郑鹏, 周吉, 吴衡, 陈硕. 中性粒细胞与淋巴细胞比值、平均血小板体积与血小板计数比值对感染性休克患者预后的评估价值[J]. 实用临床医药杂志, 2023, 27(7): 113-117, 123. DOI: 10.7619/jcmp.20230189
引用本文: 郑鹏, 周吉, 吴衡, 陈硕. 中性粒细胞与淋巴细胞比值、平均血小板体积与血小板计数比值对感染性休克患者预后的评估价值[J]. 实用临床医药杂志, 2023, 27(7): 113-117, 123. DOI: 10.7619/jcmp.20230189
ZHENG Peng, ZHOU Ji, WU Heng, CHEN Shuo. The value of neutrophil-to-lymphocyte ratio combined with mean platelet volume-to-platelet count ratio in predicting the prognosis of patients with septic shock[J]. Journal of Clinical Medicine in Practice, 2023, 27(7): 113-117, 123. DOI: 10.7619/jcmp.20230189
Citation: ZHENG Peng, ZHOU Ji, WU Heng, CHEN Shuo. The value of neutrophil-to-lymphocyte ratio combined with mean platelet volume-to-platelet count ratio in predicting the prognosis of patients with septic shock[J]. Journal of Clinical Medicine in Practice, 2023, 27(7): 113-117, 123. DOI: 10.7619/jcmp.20230189

中性粒细胞与淋巴细胞比值、平均血小板体积与血小板计数比值对感染性休克患者预后的评估价值

基金项目: 

江苏省无锡市卫生健康委科研项目 M202056

江苏大学临床医学科技发展基金项目 JLY2021220

详细信息
    通讯作者:

    周吉, E-mail: 416778003@qq.com

  • 中图分类号: R631;R446

The value of neutrophil-to-lymphocyte ratio combined with mean platelet volume-to-platelet count ratio in predicting the prognosis of patients with septic shock

  • 摘要:
    目的 

    探讨早期外周血中性粒细胞与淋巴细胞比值(NLR)、平均血小板体积与血小板计数比值(MPV/PLT)对感染性休克患者预后的评估价值。

    方法 

    回顾性分析112例住院治疗的感染性休克患者的临床资料,根据28 d预后情况分为存活组69例和死亡组43例。比较2组患者年龄、性别、入院时休克指数、氧合指数、C反应蛋白(CRP)、降钙素原(PCT)、白细胞(WBC)、血乳酸(Lac)、急性生理学与慢性健康状况评分系统Ⅱ(APACHEⅡ)评分、序贯器官衰竭评估(SOFA)评分、D-二聚体等临床资料和入院24 h内NLR、MPV/PLT。绘制受试者工作特征(ROC)曲线,评估各项指标对感染性休克患者28 d死亡风险的预测价值;采用多因素Logistic回归分析法分析感染性休克患者预后的危险因素;采用Kaplan-Meier生存曲线分析不同NLR-MPV/PLT评分与总生存时间的相关性。

    结果 

    2组患者年龄、性别、休克指数、氧合指数、CRP比较,差异无统计学意义(P>0.05);死亡组NLR、MPV/PLT、WBC、PCT、Lac、D-二聚体、APACHEⅡ评分、SOFA评分高于存活组,差异有统计学意义(P < 0.05)。NLR预测患者死亡风险的曲线下面积(AUC)为0.724,当最佳截断值为12.49时,敏感度为74.4%,特异度为68.1%;MPV/PLT预测患者死亡风险的AUC为0.731,当最佳截断值为0.10时,敏感度为74.4%,特异度为69.6%。NLR、MPV/PLT、WBC、PCT、Lac、D-二聚体是感染性休克患者28 d死亡的独立影响因素(P < 0.05)。根据NLR-MPV/PLT评分将感染性休克患者分为0分组、1分组、2分组,其28 d累积生存率分别为88.2%、70.2%、19.4%,差异有统计学意义(P < 0.05)。

    结论 

    早期NLR、MPV/PLT对感染性休克患者的预后具有较高的预测价值,可作为有效而简便的评估指标用于急诊患者的早期诊断和后续治疗的临床指导。

    Abstract:
    Objective 

    To investigate the value of early peripheral blood neutrophil-to-lymphocyte Ratio (NLR) combined with mean platelet volume-to-platelet count ratio (MPV/PLT) in evaluating the prognosis in patients with septic shock.

    Methods 

    A total of 112 patients with infectious stroke who were hospitalized were retrospectively selected. According to the prognosis of the patients within 28 days, they were divided into survival group(n=69) and death group (n=43). Age, gender, shock index, oxygenation index, C-reactive protein (CRP), procalcitonin (PCT), white blood cell (WBC), lactic acid (Lac), acute physiology and chronic health evaluation Ⅱ(APACHEⅡ) score, sequential organ failure assessment (SOFA) score, D-dimer, NLR and MPV/PLT within 24 hours after admission were recorded. The receiver operating characteristic curve (ROC) was used to evaluate the clinical predictive value of various indicators for the 28-day mortality risk of patients with septic shock. Multivariate Logistic regression was used to analyze the risk factors for the prognosis of patients with septic shock. Kaplan-Meier survival curve was used to analyze the correlations of different NLR-MPV/PLT scores with overall survival.

    Results 

    There were no significant differences in age, gender, shock index, oxygenation index, and CRP between the two groups (P>0.05). Compared with the survival group, NLR, MPV/PLT, WBC, PCT, Lac, D-dimer, APACHEⅡ score and SOFA score in the death group were higher than those in the control group(P < 0.05). The area under the curve (AUC) of NLR in predicting death risk was 0.724, when the optimal cut-off value was 12.49, the sensitivity was 74.4% and the specificity was 68.1%. The AUC for MPV/PLT in predicting death risk was 0.731, with a sensitivity of 74.4% and specificity of 69.6% when the optimal cut-off value was 0.10. NLR, MPV/PLT, WBC, PCT, Lac and D-dimer were independent influencing factors of death in septic shock patients at 28 d (P < 0.05). Patients with septic shock were divided into 0 score group, one score group, two scores group according to NLR-MPV/PLT score, the 28-day cumulative survival rates were 88.2%, 70.2% and 19.4%, respectively(P < 0.05).

    Conclusion 

    Early NLR and MPV/PLT have high predictive value for the prognosis of septic shock patients, which can be used as effective and simple evaluation index for early diagnosis of emergency patients and clinical guidance for follow-up treatment.

  • 图  1   NLR和MPV/PLT预测感染性休克患者28 d死亡风险的ROC曲线

    图  2   不同NLR-MPV/PLT评分患者的Kaplan-Meier生存曲线

    表  1   存活组与死亡组患者临床资料比较(x±s)[n(%)][M(P25, P75)]

    指标 存活组(n=69) 死亡组(n=43) χ2/t/z P
    年龄/岁 69.13±13.83 71.56±13.76 -0.905 0.376
    性别 36(52.17) 26(60.47) 0.737 0.391
    33(47.83) 17(39.53)
    既往病史 高血压病 48(69.57) 25(58.14) 1.524 0.217
    糖尿病 21(30.43) 15(34.88) 0.240 0.624
    冠心病 19(27.54) 10(23.26) 0.253 0.615
    休克指数 1.34±0.18 1.38±0.21 -1.122 0.409
    氧合指数 266.09±42.31 251.58±52.63 1.605 0.111
    CRP/(mg/L) 95.43±17.19 100.50±16.63 -1.563 0.121
    WBC/(×109/L) 12.09±5.97 15.29±7.03 -2.572 0.011
    PCT/(ng/mL) 44.37±20.64 52.99±18.58 -2.233 0.028
    Lac/(mmol/L) 5.24±2.55 6.81±2.77 -3.055 0.003
    D-二聚体/(ng/mL) 1 460.00(777.00, 2 598.00) 3 491.00(1 646.00, 6 249.00) -3.309 0.001
    NLR 10.95±6.06 15.04±4.53 -3.816 0.001
    MPV/PLT 0.09±0.05 0.13±0.06 -3.578 0.001
    APACHEⅡ评分/分 21.90±4.61 24.26±3.19 -2.942 0.004
    SOFA评分/分 9.52±2.01 10.63±2.63 -2.512 0.013
    CRP: C反应蛋白; WBC: 白细胞; PCT: 降钙素原; Lac: 乳酸; NLR: 中性粒细胞与淋巴细胞比值;
    MPV/PLT: 平均血小板体积与血小板计数比值; APACHEⅡ: 急性生理学与慢性健康状况评分系统Ⅱ;
    SOFA: 序贯器官衰竭评估。
    下载: 导出CSV

    表  2   各项指标对感染性休克患者28 d死亡风险的预测价值

    指标 AUC 敏感度/% 特异度/% 截断值 P 95%CI
    年龄/岁 0.552 79.1 33.3 65.50 0.360 0.442~0.661
    休克指数 0.546 14.0 97.1 1.65 0.411 0.435~0.658
    氧合指数 0.407 11.6 94.2 320.50 0.099 0.295~0.519
    CRP/(mg/L) 0.570 72.1 43.5 92.23 0.214 0.462~0.678
    WBC/(×109/L) 0.626 65.1 60.9 13.05 0.026 0.519~0.732
    PCT/(ng/mL) 0.631 93.0 33.3 29.00 0.020 0.528~0.734
    Lac/(mmol/L) 0.685 65.1 71.0 6.15 0.001 0.583~0.786
    D-二聚体/(ng/mL) 0.706 58.1 81.2 3 108.50 0.001 0.601~0.811
    NLR 0.724 74.4 68.1 12.49 0.001 0.631~0.817
    MPV/PLT 0.731 74.4 69.6 0.10 0.001 0.638~0.823
    APACHEⅡ评分/分 0.665 60.5 66.7 23.50 0.003 0.564~0.765
    SOFA评分/分 0.616 67.4 56.5 9.50 0.040 0.507~0.725
    下载: 导出CSV

    表  3   感染性休克患者28 d死亡风险的多因素Logistic回归分析

    因素 回归系数 标准误 Wald P OR 95%CI
    WBC 3.079 1.026 9.001 0.003 21.739 2.908~162.501
    SOFA评分 0.686 0.640 1.150 0.284 1.986 0.567~6.957
    APACHEⅡ评分 0.243 0.628 0.149 0.699 1.275 0.373~4.360
    PCT 1.772 0.882 4.039 0.044 5.885 1.045~33.149
    Lac 1.812 0.639 8.048 0.005 6.122 1.751~21.406
    D-二聚体 1.366 0.654 4.360 0.037 3.921 1.087~14.137
    NLR 1.781 0.627 8.083 0.004 5.938 1.739~20.274
    MPV/PLT 1.989 0.644 9.531 0.002 7.308 2.067~25.833
    下载: 导出CSV
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  • 收稿日期:  2023-01-29
  • 修回日期:  2023-02-12
  • 网络出版日期:  2023-04-22

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