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中性粒细胞与淋巴细胞比值、平均血小板体积与血小板计数比值对感染性休克患者预后的评估价值

The value of neutrophil-to-lymphocyte ratio combined with mean platelet volume-to-platelet count ratio in predicting the prognosis of patients with septic shock

    摘要
  • 摘要:
    目的 探讨早期外周血中性粒细胞与淋巴细胞比值（NLR）、平均血小板体积与血小板计数比值（MPV/PLT）对感染性休克患者预后的评估价值。
    方法 回顾性分析112例住院治疗的感染性休克患者的临床资料，根据28 d预后情况分为存活组69例和死亡组43例。比较2组患者年龄、性别、入院时休克指数、氧合指数、C反应蛋白（CRP）、降钙素原（PCT）、白细胞（WBC）、血乳酸（Lac）、急性生理学与慢性健康状况评分系统Ⅱ（APACHEⅡ）评分、序贯器官衰竭评估（SOFA）评分、D-二聚体等临床资料和入院24 h内NLR、MPV/PLT。绘制受试者工作特征（ROC）曲线，评估各项指标对感染性休克患者28 d死亡风险的预测价值；采用多因素Logistic回归分析法分析感染性休克患者预后的危险因素；采用Kaplan-Meier生存曲线分析不同NLR-MPV/PLT评分与总生存时间的相关性。
    结果 2组患者年龄、性别、休克指数、氧合指数、CRP比较，差异无统计学意义（P>0.05）；死亡组NLR、MPV/PLT、WBC、PCT、Lac、D-二聚体、APACHEⅡ评分、SOFA评分高于存活组，差异有统计学意义（P < 0.05）。NLR预测患者死亡风险的曲线下面积（AUC）为0.724，当最佳截断值为12.49时，敏感度为74.4%，特异度为68.1%；MPV/PLT预测患者死亡风险的AUC为0.731，当最佳截断值为0.10时，敏感度为74.4%，特异度为69.6%。NLR、MPV/PLT、WBC、PCT、Lac、D-二聚体是感染性休克患者28 d死亡的独立影响因素（P < 0.05）。根据NLR-MPV/PLT评分将感染性休克患者分为0分组、1分组、2分组，其28 d累积生存率分别为88.2%、70.2%、19.4%，差异有统计学意义（P < 0.05）。
    结论 早期NLR、MPV/PLT对感染性休克患者的预后具有较高的预测价值，可作为有效而简便的评估指标用于急诊患者的早期诊断和后续治疗的临床指导。

     

    Abstract:
    Objective To investigate the value of early peripheral blood neutrophil-to-lymphocyte Ratio (NLR) combined with mean platelet volume-to-platelet count ratio (MPV/PLT) in evaluating the prognosis in patients with septic shock.
    Methods A total of 112 patients with infectious stroke who were hospitalized were retrospectively selected. According to the prognosis of the patients within 28 days, they were divided into survival group(n=69) and death group (n=43). Age, gender, shock index, oxygenation index, C-reactive protein (CRP), procalcitonin (PCT), white blood cell (WBC), lactic acid (Lac), acute physiology and chronic health evaluation Ⅱ(APACHEⅡ) score, sequential organ failure assessment (SOFA) score, D-dimer, NLR and MPV/PLT within 24 hours after admission were recorded. The receiver operating characteristic curve (ROC) was used to evaluate the clinical predictive value of various indicators for the 28-day mortality risk of patients with septic shock. Multivariate Logistic regression was used to analyze the risk factors for the prognosis of patients with septic shock. Kaplan-Meier survival curve was used to analyze the correlations of different NLR-MPV/PLT scores with overall survival.
    Results There were no significant differences in age, gender, shock index, oxygenation index, and CRP between the two groups (P>0.05). Compared with the survival group, NLR, MPV/PLT, WBC, PCT, Lac, D-dimer, APACHEⅡ score and SOFA score in the death group were higher than those in the control group(P < 0.05). The area under the curve (AUC) of NLR in predicting death risk was 0.724, when the optimal cut-off value was 12.49, the sensitivity was 74.4% and the specificity was 68.1%. The AUC for MPV/PLT in predicting death risk was 0.731, with a sensitivity of 74.4% and specificity of 69.6% when the optimal cut-off value was 0.10. NLR, MPV/PLT, WBC, PCT, Lac and D-dimer were independent influencing factors of death in septic shock patients at 28 d (P < 0.05). Patients with septic shock were divided into 0 score group, one score group, two scores group according to NLR-MPV/PLT score, the 28-day cumulative survival rates were 88.2%, 70.2% and 19.4%, respectively(P < 0.05).
    Conclusion Early NLR and MPV/PLT have high predictive value for the prognosis of septic shock patients, which can be used as effective and simple evaluation index for early diagnosis of emergency patients and clinical guidance for follow-up treatment.

     

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