N6-甲基腺苷RNA甲基化修饰在肾纤维化中的研究进展

Advances in N6-methyladenosine RNA methylation modifications in renal fibrosis

摘要: N6-甲基腺苷(m6A)是真核细胞最丰富的转录后修饰类型。多种类型的RNA, 如信使RNA (mRNA)、长链非编码RNA (lncRNA)、环状RNA (circRNA)、微小RNA (miRNA)、转移RNA (tRNA)、核糖体RNA (rRNA)等，均可发生m6A甲基化修饰。近期研究发现，异常m6A甲基化修饰是肾脏疾病中肾纤维化的“导火索”，可通过不同的靶点、信号通路等对肾间质纤维化产生促进或抑制作用，但具体机制仍需进一步研究。本文对m6A甲基化修饰在肾纤维化中的研究进展进行综述，旨在为临床新药研发提供新思路。

Abstract: N6-methyladenosine RNA (m6A) is the most abundant type of post-transcriptional modification in eukaryotic cells. Various RNA types, such as messenger RNA (mRNA), long non-coding RNA (lncRNA), circular RNA (circRNA), microRNA (miRNA) and transfer RNA (tRNA), can undergo m6A methylation modifications. Recently, aberrant m6A methylation modifications have been found to be the trigger of renal fibrosis in kidney diseases, which can promote or inhibit interstitial fibrosis through different targets and signaling pathways, but the exact mechanism needs further investigation. This paper aimed to review the mechanism of m6A methylation modification in renal fibrosis and provide new ideas for the development of new clinical drugs.