幽门螺杆菌中性粒细胞激活蛋白相关疾病预防及治疗研究进展

Research progress on prevention and treatment of Helicobacter pylori neutrophil-activating protein related diseases

摘要: 幽门螺杆菌(H. pylori)中性粒细胞激活蛋白(HP-NAP)是新近发现的H. pylori的主要毒力因子之一, 几乎所有H. pylori菌株都有表达。HP-NAP被激活后，可刺激中性粒细胞、单核细胞、树突状细胞、肥大细胞和淋巴细胞，参与炎症的发展和组织损伤。本文对HP-NAP在相关疾病的预防、治疗中的最新研究进展予以综述。

Abstract: Helicobacter pylori (H. pylori) neutrophil-activating protein (HP-NAP) is one of the newly discovered main virulence factors of H. pylori, and is expressed in almost all strains of H. pylori. After being activated, HP-NAP can participate in the development of inflammation and tissue damage by stimulating neutrophils, monocytes, dendritic cells, mast cells and lymphocytes. This paper reviewed the latest research progress of HP-NAP in the prevention and treatment of related diseases.