Abstract: Clonorchiasis sinensis is a zoonotic parasitic disease with hidden onset and atypical clinical symptoms, which is prone to misdiagnosis and missed diagnosis. This study reported the diagnosis and treatment process of a Clonorchiasis sinensis patient with hepatic occupied disease as initial symptom. Through literature review, the clinical manifestations, epidemic status as well as diagnosis and treatment points of the disease were reviewed, and its relationship with intrahepatic cholangiocarcinoma was analyzed to improve clinical doctors'understanding of the diagnosis and treatment of Clonorchiasis sinensis and implement early diagnosis and treatment.