Abstract: Patients are prone to present peritonitis and catheter-related infections during peritoneal dialysis treatment, and the combined treatment of vancomycin and cefoperazone sulbactam fails to achieve the satisfactory anti-infective effect, but the combined treatment of Tuoli Xiaodu Powder and Qianjin Weijing Decoction can effectively control the infection. The patient's illness was protracted, with insufficient vital energy and the invasion of pathogenic factors, so the treatment was focused on invigorating qi and enriching blood, clearing heat and detoxifying, and removing abscesses. Tuoli Xiaodu Powder combined with Qianjin Weijing Decoction with modifications can timely control the patient's infection and provide a new option for clinical treatment of peritonitis and catheter-related infections.