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固有淋巴细胞亚群及其活化因子水平与高血压性基底节区脑出血术后颅内感染的关系研究

Relationships of innate lymphocyte subsets and their activation factors with postoperative intracranial infection in patients with hypertensive basal ganglia hemorrhage

    摘要
  • 摘要:
    目的  探讨外周血固有淋巴细胞(ILCs)亚群及其活化因子水平与高血压性基底节区脑出血患者术后颅内感染的关系。
    方法  选取高血压性基底节区脑出血术后颅内感染患者(感染组, n=105)和未感染患者(未感染组, n=105)作为研究对象，根据术后颅内感染严重程度将感染组患者分为轻度感染组(n=33)、中度感染组(n=50)和重度感染组(n=22), 根据不同预后将感染组患者分为预后良好组53例和预后不良组52例。比较各组外周血ILCs亚群(ILC1、ILC2、ILC3)、白细胞介素(IL)-12、IL-33、IL-1β水平。分析各指标与颅内感染程度的相关性及对感染患者预后不良的预测价值。
    结果  与未感染组比较，感染组ILC2、ILC3水平均降低, IL-12、IL-33和IL-1β水平均升高，差异有统计学意义(P < 0.05)。感染患者ILC2、ILC3水平随着感染程度的增加而下降, IL-12、IL-33和IL-1β水平随着感染程度的增加而上升，差异有统计学意义(P < 0.05)。颅内感染患者ILC2、ILC3水平均与感染严重程度呈负相关(r=-0.721、-0.596, P < 0.001), IL-12、IL-33、IL-1β水平均与感染严重程度呈正相关(r=0.576、0.483、0.553, P < 0.001)。外周血ILC2、ILC3、IL-12、IL-33、IL-1β联合预测感染患者预后不良的AUC(0.930)和特异度(84.91%)大于或高于各指标单独预测。
    结论  高血压性基底节区脑出血术后颅内感染患者外周血ILC2、ILC3、IL-12、IL-33和IL-1β水平均与感染严重程度有关，5项指标联合检测对感染患者不良预后具有良好的预测价值。

     

    Abstract:
    Objective  To investigate the relationships of the subsets and activation factors of peripheral blood innate lymphocytes (ILCs) with postoperative intracranial infection in patients with hypertensive basal ganglia hemorrhage.
    Methods  A total of 105 patients with postoperative intracranial infection (infection group) and 105 patients without infection (non-infection group) were selected as research subjects. The patients in the infection group were divided into mild infection group (n=33), moderate infection group (n=50) and severe infection group (n=22) according to the severity of postoperative intracranial infection. The patients in the infection group were divided into good prognosis group (n=53) and poor prognosis group (n=52) according to different outcomes. The subsets of ILCs (ILC1, ILC2, ILC3), interleukin (IL)-12, IL-33, IL-1β levels in peripheral blood were compared among the groups. The correlation between each index and the severity of intracranial infection and the predictive value of poor prognosis in infected patients were analyzed.
    Results  Compared with the non-infection group, the levels of ILC2 and ILC3 in the infection group were reduced, while the levels of IL-12, IL-33 and IL-1β were increased (P < 0.05). The levels of ILC2 and ILC3 in infected patients decreased with the increase of infection severity, while the levels of IL-12, IL-33 and IL-1β increased with the increase of infection severity (P < 0.05). The levels of ILC2 and ILC3 in patients with intracranial infection werenegatively correlated with the severity of infection (r=-0.721, -0.596, P < 0.001), while the levels of IL-12, IL-33 and IL-1β were positively correlated with the severity of infection (r=0.576, 0.483, 0.553, P < 0.001). The combined prediction of peripheral blood ILC2, ILC3, IL-12, IL-33 and IL-1β for poor prognosis in infected patients had a higher AUC (0.930) and specificity (84.91%) than each index alone.
    Conclusion  The levels of peripheral blood ILC2, ILC3, IL-12, IL-33 and IL-1β in patients with postoperative intracranial infection after hypertensive basal ganglia hemorrhage are associated with the severity of infection. The combined detection of five indicators has a good predictive value for poor prognosis in infected patients.

     

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