Effect evaluation of Liuhe Pills combined with sitz bath in povidone iodine diluent for nursing of perianal infection in patients with hematologic malignancy
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摘要:目的
观察六合丹湿敷联合聚维酮碘稀释液坐浴在血液恶性肿瘤患者肛周感染护理中的应用效果。
方法选择2020年1月—2022年12月在血液内科住院的180例血液恶性肿瘤合并肛周感染患者为研究对象。根据入院的先后顺序，将患者分为对照组(n=90)和试验组(n=90)。对照组在常规肛周清洁护理的基础上进行1∶200聚维酮碘稀释液坐浴，试验组在对照组的基础上给予六合丹外敷。比较2组患者临床疗效、肛周疼痛评分、肛周不良反应。
结果试验组治疗总有效率为95.56%, 高于对照组的83.33%, 差异有统计学意义(P < 0.01)。2组患者干预后2、3、7、14 d的肛周疼痛评分比较，差异有统计学意义(P < 0.05或P < 0.01)。2组患者均未出现严重不良反应; 对照组不良反应发生率为14.44%, 试验组不良反应发生率为16.67%, 2组差异无统计学意义(P>0.05)。
结论六合丹联合聚维酮碘稀释液坐浴在血液恶性肿瘤患者肛周感染护理中应用效果显著，可缓解疼痛，促进康复。
Abstract:ObjectiveTo observe the effect of Liuhe Pills combined with sitz bath in povidone iodine diluent for nursing of perianal infection in patients with hematologic malignancy.
MethodsA total of 180 hematologic malignancy patients complicated with perianal infection in the Department of Hematology from January 2020 to December 2022 were selected as research objects. According to the order of hospital admission, they were divided into control group (n=90) and experimental group (n=90). The control group was treated with sitz bath in 1∶200 povidone iodine diluent on the basis of routine perianal cleaning care, while the experimental group was treated with external application of Liuhe Pills on the basis of the control group. The clinical efficacy, perianal pain score and perianal adverse reactions were compared between the two groups.
ResultsAfter intervention, the total effective rate of the experimental group was 95.56%, which was significantly higher than 83.33% of the control group (P < 0.01). There were significant differences in perianal pain scores between two groups at 2, 3, 7 and 14 days after intervention (P < 0.05 or P < 0.01). Patients in both groups did not have serious adverse reactions; the incidence of adverse reactions was 14.44% in the control group, which showed no significant difference when compared to 16.67% in the experimental group (P>0.05).
ConclusionApplication of Liuhe Pills combined with sitz bath in povidone iodine diluent is effective in the nursing of perianal infection in patients with hematologic malignancy, which can alleviate the pain and promote the recovery.
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表 1 2组患者基线资料比较(x±s)[n(%)][M(P25, P75)]
基线资料 分类 对照组(n=90) 试验组(n=90) P 性别 男 55(61.11) 48(53.33) 0.063 女 35(38.89) 42(46.67) 年龄/岁 45.45±17.29 42.73±15.95 0.264 婚姻状况 已婚 80(88.89) 71(78.89) 0.459 未婚 10(11.11) 19(21.11) 文化程度 中专及以下 38(42.22) 47(52.22) 0.460 高中、大专 42(46.67) 33(36.67) 本科及以上 10(11.11) 10(11.11) 诊断 急性淋巴细胞白血病 26(28.89) 22(24.44) 0.074 急性髓细胞白血病 52(57.78) 64(71.11) 淋巴瘤 4(4.44) 3(3.33) 骨髓增生异常综合征 8(8.89) 1(1.12) 复发难治 否 58(64.44) 65(72.22) 0.534 是 32(35.56) 25(27.78) 肛周感染史 否 57(63.33) 49(54.44) 0.337 是 33(36.67) 41(45.56) 白细胞计数/(×109/L) 3.17(1.26, 4.97) 3.55(1.59, 8.68) 0.072 血红蛋白计数/(×109/L) 78.57(68.40, 97.72) 73.87(63.43, 90.22) 0.163 白蛋白计数/(g/L) 38.10(34.88, 41.23) 36.30(32.60, 39.38) 0.110 降钙素原/(ng/mL) 0.37(0.16, 0.98) 0.26(0.13, 0.69) 0.236 C反应蛋白/(mg/L) 33.10(13.80, 82.10) 29.70(12.50, 73.40) 0.097 白细胞介素-6/(pg/mL) 49.80(27.90, 83.20) 45.50(27.20, 79.60) 0.324 
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表 2 2组患者肛周感染临床疗效比较[n(%)]
组别 治愈 好转 无效 总有效 对照组(n=90) 46(51.11) 29(32.22) 15(16.67) 75(83.33) 试验组(n=90) 72(80.00) 14(15.56) 4(4.44) 86(95.56)** 与对照组比较, **P < 0.01。
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表 3 2组患者肛周疼痛评分比较(x±s)
分 时点 对照组(n=90) 试验组(n=90) 0 d 5.71±1.11 5.90±1.25 1 d 5.43±1.64 5.53±1.54 2 d 4.42±1.50 3.30±1.11** 3 d 4.16±1.30 2.27±1.04** 7 d 3.46±0.97 2.33±0.78* 14 d 1.58±0.55 0.63±0.32** 与对照组比较, *P < 0.05, **P < 0.01。
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表 4 2组患者不良反应比较[n(%)]
组别 肛周皮肤干燥 局部皮肤瘙痒 色素沉着 合计 对照组(n=90) 5(5.56) 2(2.22) 6(6.67) 13(14.44) 试验组(n=90) 9(10.00) 3(3.33) 3(3.33) 15(16.67)
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