Effect of nursing-led auricular acupressure on chemotherapy-induced peripheral neuropathy of patients with breast cancer
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摘要:目的
观察护理主导的耳穴压豆疗法在改善紫杉醇类药物化疗乳腺癌患者周围神经病变症状中的效果。
方法将86例患者随机分为研究组和对照组，每组43例。研究组采用传统西医治疗结合耳穴压豆法进行干预，对照组采用传统西医治疗。比较2组患者临床疗效及周围神经病变症状评分。
结果治疗后, 2组患者肢体麻木、肢体疼痛、倦怠乏力和腱反射评分均低于治疗前，且研究组患者上述评分低于对照组，差异均有统计学意义(P < 0.05)。研究组患者总有效率为88.4%(38/43), 高于对照组的74.4%(32/43), 差异有统计学意义(P < 0.05)。
结论护理主导的耳穴压豆疗法联合甲钴胺可改善接受紫杉醇类药物治疗的乳腺癌患者周围神经毒性症状，具有无创简单、安全灵活、经济实用、依从性好等优势。
Abstract:ObjectiveTo observe the effect of nursing-led auricular acupressure therapy in improving the symptoms of peripheral neuropathy in breast cancer patients with chemotherapy of paclitaxel.
MethodsA total of 86 patients were randomly divided into study group and control group, with 43 cases in each group. The study group was treated with traditional western medicine and auricular acupressure, while the control group was treated with traditional western medicine alone. The clinical efficacy and scores of peripheral neuropathy symptoms were compared between the two groups.
ResultsAfter treatment, the scores of limb numbness, limb pain, fatigue and tendon reflex in both groups were significantly lower than those before treatment, and the scores of the above symptoms in the study group were significantly lower than those in the control group (P < 0.05).The total effective rate of the study group was 88.4% (38/43), which was significantly higher than 74.4% (32/43) in the control group (P < 0.05).
ConclusionThe nursing-led auricular acupressure therapy combined with mecobalamin can improve the symptoms of peripheral neurotoxicity in breast cancer patients treated with paclitaxel, with the advantages of non-invasiveness, simplicity, safety, flexibility, cost-effectiveness, and good compliance.
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Keywords:
- nursing /
- auricular acupressure therapy /
- breast cancer /
- chemotherapy /
- peripheral neuropathy /
- paclitaxel
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表 1 2组患者一般资料比较[n(%)]
变量 分类 对照组(n=43) 研究组(n=43) χ2 P 年龄 ≤40岁 7(16.3) 8(18.6) 0.081 0.760 >40岁 36(83.7) 35(81.4) 绝经情况 未绝经 22(51.2) 19(44.2) 0.420 0.517 已绝经 21(48.8) 24(55.8) 分期 Ⅱ期 32(74.4) 34(79.1) 0.261 0.610 Ⅲ期 11(25.6) 9(20.9) 病理类型 浸润性导管癌 38(88.4) 40(93.0) 0.551 0.458 浸润性小叶癌 5(11.6) 3(7.0) 紫杉醇类药物 紫杉醇 35(81.4) 38(88.4) 0.816 0.366 白蛋白结合型紫杉醇 8(18.6) 5(11.6) 蒽环类药物 表柔比星(法玛新) 15(34.9) 18(41.9) 0.443 0.506 表柔比星(艾达生) 28(65.1) 25(58.1) 
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表 2 2组患者治疗前后周围神经病变症状评分比较(x±s)
分 周围神经病变症状 时点 对照组(n=43) 研究组(n=43) 肢体麻木 治疗前 2.02±0.67 1.95±0.79 治疗后 1.42±0.55* 0.98±0.83*# 肢体刺痛 治疗前 1.93±0.77 2.00±0.79 治疗后 1.56±0.59* 1.09±0.48*# 疲倦乏力 治疗前 1.91±0.68 1.88±0.82 治疗后 1.67±0.72* 1.14±0.47*# 腱反射 治疗前 1.88±0.69 1.86±0.97 治疗后 1.77±0.61* 1.40±0.82*# 与治疗前比较, * P < 0.05; 与对照组比较, #P < 0.05。
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表 3 2组患者治疗后临床治疗效果比较[n(%)]
组别 n 显效 有效 无效 总有效 对照组 43 10(23.3) 22(51.1) 11(25.6) 32(74.4) 研究组 43 22(51.2) 16(37.2) 5(11.6) 38(88.4)* 与对照组比较, * P < 0.05。
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