新型冠状病毒感染对B细胞非霍奇金淋巴瘤的影响综述

吴炫璐, 丁心, 郑焱华, 王晓雪

吴炫璐, 丁心, 郑焱华, 王晓雪. 新型冠状病毒感染对B细胞非霍奇金淋巴瘤的影响综述[J]. 实用临床医药杂志, 2024, 28(22): 137-142. DOI: 10.7619/jcmp.20241910
引用本文: 吴炫璐, 丁心, 郑焱华, 王晓雪. 新型冠状病毒感染对B细胞非霍奇金淋巴瘤的影响综述[J]. 实用临床医药杂志, 2024, 28(22): 137-142. DOI: 10.7619/jcmp.20241910
WU Xuanlu, DING Xin, ZHENG Yanhua, WANG Xiaoxue. Effect of Coronavirus Disease 2019 infection on B-cell non-Hodgkin lymphoma[J]. Journal of Clinical Medicine in Practice, 2024, 28(22): 137-142. DOI: 10.7619/jcmp.20241910
Citation: WU Xuanlu, DING Xin, ZHENG Yanhua, WANG Xiaoxue. Effect of Coronavirus Disease 2019 infection on B-cell non-Hodgkin lymphoma[J]. Journal of Clinical Medicine in Practice, 2024, 28(22): 137-142. DOI: 10.7619/jcmp.20241910

新型冠状病毒感染对B细胞非霍奇金淋巴瘤的影响综述

基金项目: 

国家自然科学基金项目 81900153

辽宁省科学技术基金项目 2022-YGJC-62

详细信息
    通讯作者:

    王晓雪

  • 中图分类号: R551.2;R563.1;R329.2

Effect of Coronavirus Disease 2019 infection on B-cell non-Hodgkin lymphoma

  • 摘要:

    新型冠状病毒感染(COVID-19)是由严重急性呼吸道综合征冠状病毒2引起的一种传染病。B细胞淋巴瘤患者因疾病本身及其治疗可能导致免疫功能低下,成为COVID-19易感及重症的高危人群。因此,分析确诊COVID-19的B细胞非霍奇金淋巴瘤患者的基线特征、探究共同易感因素、评估疫苗接种效果及免疫治疗(尤其是CD20单抗)导致的免疫缺陷问题具有重要意义。针对发生COVID-19的B细胞非霍奇金淋巴瘤患者,需要进行个体化风险因素的评估。本综述就淋巴瘤患者对COVID-19的免疫应答展开阐述,总结发生COVID-19后的淋巴瘤患者特征,分析疫苗在这类群体中的有效性,探讨COVID-19对B细胞非霍奇金淋巴瘤病及抗肿瘤治疗的影响与相关风险因素,为拟定治疗策略及临床管理提供建议。

    Abstract:

    Coronavirus Disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with B-cell lymphoma may experience immunodeficiency due to the disease itself and its treatment, making them a high-risk group for susceptibility and severe outcomes of COVID-19. Therefore, it is crucial to analyze the baseline characteristics of B-cell non-Hodgkin lymphoma patients diagnosed with COVID-19, investigate common risk factors, evaluate the efficacy of vaccination and assess the immune deficiencies induced by immunotherapy, particularly CD20 monoclonal antibodies. For B-cell NHL patients with COVID-19, an individualized assessment of risk factors is necessary. This review discussed the immune response of lymphoma patients to COVID-19, summarized the characteristics of lymphoma patients following COVID-19, analyzed the vaccine effectiveness in this population, and explored the impact of COVID-19 on the onset and anti-tumor treatment of B-cell non-Hodgkin lymphoma, along with associated risk factors, aiming to provide recommendations for formulating treatment strategies and clinical management.

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出版历程
  • 收稿日期:  2024-05-08
  • 修回日期:  2024-07-21
  • 刊出日期:  2024-11-27

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