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血清肿瘤坏死因子α刺激基因6蛋白和ⅩⅥ型胶原蛋白预测溃疡性结肠炎患者预后的价值

Values of serum tumor necrosis factor-α stimulated gene 6 protein and type ⅩⅥ collagen in predicting prognosis of patients with ulcerative colitis

    摘要
  • 摘要:
    目的 分析血清肿瘤坏死因子α刺激基因6蛋白(TSG-6)、ⅩⅥ型胶原蛋白(col-16)预测溃疡性结肠炎(UC)患者预后的价值。
    方法 选取160例UC患者为UC组，另选取160例志愿者为对照组，比较2组血清TSG-6、col-16水平。参照改良Mayo评分标准将UC组患者分为轻度组(n=63)、中度组(n=52)、重度组(n=45), 比较3组血清TSG-6、col-16水平。根据肠镜复查结果将UC组患者分为预后良好组(n=121)和预后不良组(n=39), 比较2组血清TSG-6、col-16水平。采用Spearman相关性分析法探讨血清TSG-6、col-16与改良Mayo评分的相关性; 采用Logistic回归分析法探讨血清TSG-6、col-16对UC组患者预后的影响; 采用受试者工作特征(ROC)曲线评估血清TSG-6、col-16预测UC组患者预后的价值。
    结果 UC组血清TSG-6、col-16水平高于对照组，差异有统计学意义(P < 0.01)。中度组、重度组血清TSG-6、col-16水平高于轻度组，重度组血清TSG-6、col-16水平高于中度组，差异均有统计学意义(P < 0.01)。预后不良组血清TSG-6、col-16水平高于预后良好组，差异有统计学意义(P < 0.01)。Spearman相关性分析结果显示血清TSG-6、col-16与改良Mayo评分均呈正相关性(r=0.691, P < 0.05; r=0.635, P < 0.05)。Logistic分析结果显示血清TSG-6、col-16均是预后不良的危险因素(P < 0.001)。ROC曲线分析显示，血清TSG-6、col-16预测UC组患者预后不良的曲线下面积分别为0.773、0.765。
    结论 UC患者血清TSG-6、col-16呈异常升高状态，且与患者病情严重程度及预后存在一定的相关性，可作为预后不良的预测指标。

     

    Abstract:
    Objective To analyze the values of serum tumor necrosis factor-α stimulated gene 6 protein (TSG-6) and type ⅩⅥ collagen (col-16) in predicting the prognosis of patients with ulcerative colitis (UC).
    Methods A total of 160 patients with UC were enrolled as UC group, another 160 volunteers were selected as control group, and the levels of serum TSG-6 and col-16 were compared between the two groups. According to the modified Mayo scoring criteria, patients in the UC group were divided into mild group (n=63), moderate group (n=52), and severe group (n=45), and the levels of serum TSG-6 and col-16 were compared among the three groups. Based on the colonoscopy follow-up results, patients in the UC group were divided into good prognosis group (n=121) and poor prognosis group (n=39), and the levels of serum TSG-6 and col-16 were compared between the two groups. Spearman correlation analysis was used to explore the correlations of serum TSG-6 and col-16 with the modified Mayo score. Logistic regression analysis was used to investigate the impact of serum TSG-6 and col-16 on the prognosis of patients in the UC group. Receiver operating characteristic (ROC) curve was used to assess the values of serum TSG-6 and col-16 in predicting the prognosis of patients in the UC group.
    Results The levels of serum TSG-6 and col-16 in the UC group were significantly higher than those in the control group (P < 0.01). The levels of serum TSG-6 and col-16 in the moderate and severe groups were significantly higher than those in the mild group, and the levels of serum TSG-6 and col-16 in the severe group were significantly higher than those in the moderate group (P < 0.01). The levels of serum TSG-6 and col-16 in the poor prognosis group were significantly higher than those in the good prognosis group (P < 0.01). Spearman correlation analysis showedthat serum TSG-6 and col-16 were positively correlated with the modified Mayo score (r=0.691, P < 0.05; r=0.635, P < 0.05). Logistic analysis results showed that serum TSG-6 and col-16 were risk factors for poor prognosis (P < 0.001). ROC curve analysis showed that the areas under the curve for predicting poor prognosis in patients with UC were 0.773 and 0.765 for serum TSG-6 and col-16, respectively.
    Conclusion The levels of serum TSG-6 and col-16 are abnormally elevated in patients with UC, and there is a certain correlation of the two indexes with the severity and prognosis of disease, and the two indexes can be used as predictors of poor prognosis.

     

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